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- W2169661816 abstract "Evidence is accumulating which indicates that cyclooxygenase-2 (COX-2) is involved in the pathogenesis of colorectal cancer. We evaluated the expression of COX-2 in replication error-positive (RER) colon cancers, colon cancers metastatic to liver and azoxymethane (AOM)-induced rat colonic tumors. Immunohistochemistry showed that COX-2 was low to undetectable in normal human mucosa, but abundant in the RER adenocarcinomas we examined. COX-2 immunoreactivity in metastatic colon cancers was less abundant, but clearly detectable. In the colon of AOM-treated rats, COX-2 protein was not detectable in normal mucosa, but present in most of the epithelial cells comprising the tumors. The TGF-β1 staining pattern in these human and rat tumors was similar to that observed for COX-2. The role of TGF-β in RER adenocarcinomas is complex because of the increased mutation rate of TGF-β type II receptors. Northern analysis showed abundant TGF-β1 mRNA in AOM-induced tumors, but not in paired mucosa. TGF-β1 induced the expression of COX-2 mRNA and protein in intestinal epithelial cells (IEC-6). Chronic TGF-β1 treatment caused a TGF-β-dependent overexpression of COX-2 in rat intestinal epithelial cells (RIE-1). TGF-β1 may regulate COX-2 expression during the colonic adenoma to carcinoma sequence." @default.
- W2169661816 created "2016-06-24" @default.
- W2169661816 creator A5005959278 @default.
- W2169661816 date "1999-02-01" @default.
- W2169661816 modified "2023-10-16" @default.
- W2169661816 title "Coordinate regulation of cyclooxygenase-2 and TGF-1 in replication error-positive colon cancer and azoxymethane-induced rat colonic tumors" @default.
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- W2169661816 doi "https://doi.org/10.1093/carcin/20.2.185" @default.
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