FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169662473> ?p ?o ?g. }

• W2169662473 endingPage "508" @default.
• W2169662473 startingPage "496" @default.
• W2169662473 abstract "This study investigated the disposition patterns of cocaine and opiates into hair and fingernail specimens collected from 8 volunteers enrolled in a 10-week inpatient clinical study. All subjects were African-American males with a confirmed drug use history. Scalp hair and fingernail scrapings were collected weekly throughout the course of the study. Head hair was collected from the posterior vertex region, and fingernail scrapings were collected along the entire ventral surface of the nail plate. The specimens were introduced to successive decontamination washes including an isopropanol wash and three phosphate buffer washes. All decontamination washes were collected and analyzed. All specimens were enzymatically digested prior to being subjected to solid-phase extraction and derivatization. Analyses were performed using electron impact gas chromatography-mass spectrometry. Analytes investigated included eight cocaine analytes and five codeine analytes. The limit of quantitation for all analytes ranged from 0.1 to 0.5 ng/mg for both matrices. Cocaine was present at the highest concentrations of any analyte in both hair and nail. Benzoylecgonine and ecgonine methyl ester were the primary metabolites in both matrices and were typically less than 15% of cocaine concentrations. Codeine was the only opiate analyte identified in either hair or nail. Observed drug disposition profiles were different for hair and nails. A significant dose-response relationship was observed for hair specimens. The mean peak concentrations in hair after low dosing were half the concentration observed after high-dose administration. Generally, no clear relationship was evident between nail drug concentrations and dose. Decontamination washes removed less than 20% of the total drug present in hair, but removed most of the drug concentrations (60–100%) in nail. This investigation demonstrated that higher concentrations of drug were found in the subjects' hair than in their fingernails and that cocaine was found in both matrices at a greater concentration than codeine. Although both hair and nail have similar physical and chemical properties and may share common mechanisms of drug incorporation, this clinical study suggests that there are distinct differences in their disposition profiles." @default.
• W2169662473 created "2016-06-24" @default.
• W2169662473 creator A5072542414 @default.
• W2169662473 creator A5080939734 @default.
• W2169662473 creator A5088248944 @default.
• W2169662473 creator A5089636480 @default.
• W2169662473 date "2000-10-01" @default.
• W2169662473 modified "2023-10-15" @default.
• W2169662473 title "The Disposition of Cocaine and Opiate Analytes in Hair and Fingernails of Humans Following Cocaine and Codeine Administration" @default.
• W2169662473 cites W1488099200 @default.
• W2169662473 cites W1502956194 @default.
• W2169662473 cites W1532482858 @default.
• W2169662473 cites W1535192234 @default.
• W2169662473 cites W1965478498 @default.
• W2169662473 cites W1991353947 @default.
• W2169662473 cites W1992797095 @default.
• W2169662473 cites W2003646174 @default.
• W2169662473 cites W2012278634 @default.
• W2169662473 cites W2020080810 @default.
• W2169662473 cites W2050347528 @default.
• W2169662473 cites W2065697285 @default.
• W2169662473 cites W2067174726 @default.
• W2169662473 cites W2079211084 @default.
• W2169662473 cites W2080771400 @default.
• W2169662473 cites W2089971313 @default.
• W2169662473 cites W2102692243 @default.
• W2169662473 cites W2105689410 @default.
• W2169662473 cites W2107499859 @default.
• W2169662473 cites W2108391354 @default.
• W2169662473 cites W2111718145 @default.
• W2169662473 cites W2125824907 @default.
• W2169662473 cites W2153320880 @default.
• W2169662473 cites W2155874918 @default.
• W2169662473 cites W43826506 @default.
• W2169662473 cites W582597563 @default.
• W2169662473 cites W598552629 @default.
• W2169662473 cites W88341832 @default.
• W2169662473 doi "https://doi.org/10.1093/jat/24.7.496" @default.
• W2169662473 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11043652" @default.
• W2169662473 hasPublicationYear "2000" @default.
• W2169662473 type Work @default.
• W2169662473 sameAs 2169662473 @default.
• W2169662473 citedByCount "60" @default.
• W2169662473 countsByYear W21696624732012 @default.
• W2169662473 countsByYear W21696624732013 @default.
• W2169662473 countsByYear W21696624732014 @default.
• W2169662473 countsByYear W21696624732015 @default.
• W2169662473 countsByYear W21696624732016 @default.
• W2169662473 countsByYear W21696624732017 @default.
• W2169662473 countsByYear W21696624732018 @default.
• W2169662473 countsByYear W21696624732019 @default.
• W2169662473 countsByYear W21696624732020 @default.
• W2169662473 countsByYear W21696624732021 @default.
• W2169662473 crossrefType "journal-article" @default.
• W2169662473 hasAuthorship W2169662473A5072542414 @default.
• W2169662473 hasAuthorship W2169662473A5080939734 @default.
• W2169662473 hasAuthorship W2169662473A5088248944 @default.
• W2169662473 hasAuthorship W2169662473A5089636480 @default.
• W2169662473 hasBestOaLocation W21696624731 @default.
• W2169662473 hasConcept C10390740 @default.
• W2169662473 hasConcept C142724271 @default.
• W2169662473 hasConcept C179998833 @default.
• W2169662473 hasConcept C185592680 @default.
• W2169662473 hasConcept C191897082 @default.
• W2169662473 hasConcept C192562407 @default.
• W2169662473 hasConcept C204787440 @default.
• W2169662473 hasConcept C2776923573 @default.
• W2169662473 hasConcept C2777389121 @default.
• W2169662473 hasConcept C2777537440 @default.
• W2169662473 hasConcept C2777852167 @default.
• W2169662473 hasConcept C2777866328 @default.
• W2169662473 hasConcept C2780026642 @default.
• W2169662473 hasConcept C2781400828 @default.
• W2169662473 hasConcept C43617362 @default.
• W2169662473 hasConcept C55493867 @default.
• W2169662473 hasConcept C71924100 @default.
• W2169662473 hasConcept C98274493 @default.
• W2169662473 hasConceptScore W2169662473C10390740 @default.
• W2169662473 hasConceptScore W2169662473C142724271 @default.
• W2169662473 hasConceptScore W2169662473C179998833 @default.
• W2169662473 hasConceptScore W2169662473C185592680 @default.
• W2169662473 hasConceptScore W2169662473C191897082 @default.
• W2169662473 hasConceptScore W2169662473C192562407 @default.
• W2169662473 hasConceptScore W2169662473C204787440 @default.
• W2169662473 hasConceptScore W2169662473C2776923573 @default.
• W2169662473 hasConceptScore W2169662473C2777389121 @default.
• W2169662473 hasConceptScore W2169662473C2777537440 @default.
• W2169662473 hasConceptScore W2169662473C2777852167 @default.
• W2169662473 hasConceptScore W2169662473C2777866328 @default.
• W2169662473 hasConceptScore W2169662473C2780026642 @default.
• W2169662473 hasConceptScore W2169662473C2781400828 @default.
• W2169662473 hasConceptScore W2169662473C43617362 @default.
• W2169662473 hasConceptScore W2169662473C55493867 @default.
• W2169662473 hasConceptScore W2169662473C71924100 @default.
• W2169662473 hasConceptScore W2169662473C98274493 @default.
• W2169662473 hasIssue "7" @default.
• W2169662473 hasLocation W21696624731 @default.
• W2169662473 hasLocation W21696624732 @default.

• next