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- W2169662921 endingPage "251" @default.
- W2169662921 startingPage "237" @default.
- W2169662921 abstract "Oligonucleotides are promising tools for in vitro studies where specific downregulation of proteins is required. In addition, antisense oligonucleotides have been studied in vivo and have entered clinical trials as new chemical entities with various therapeutic targets such as antiviral drugs or for tumour treatments. The formulation of these substances were widely studied in the past. With this review we will focus on peptides used as drug delivery vehicles for oligonucleotides. Different strategies are summarised. Cationically charged peptides from different origins were used e.g. as cellular penetration enhancers or nuclear localisation tool. Examples are given for Poly-L-lysine alone or in combination with receptor specific targeting ligands such as asialoglycoprotein, galactose, growth factors or transferrin. Another large group of peptides are those with membrane translocating properties. Fusogenic peptides rich in lysine or arginine are reviewed. They have been used for DNA complexation and condensation to form transport vehicles. Some of them, additionally, have so called nuclear localisation properties. Here, DNA sequences, which facilitate intracellular trafficking of macromolecules to the nucleus were explored. Summarizing the present literature, peptides are interesting pharmaceutical excipients and it seems to be feasible to combine the specific properties of peptides to improve drug delivery devices for oligonucleotides in the future." @default.
- W2169662921 created "2016-06-24" @default.
- W2169662921 creator A5018455837 @default.
- W2169662921 creator A5075109026 @default.
- W2169662921 creator A5082616738 @default.
- W2169662921 date "2004-09-01" @default.
- W2169662921 modified "2023-10-03" @default.
- W2169662921 title "Drug delivery of oligonucleotides by peptides" @default.
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