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• W2169663960 abstract "Abstract Hypoxia‐inducible factor‐1 alpha (HIF‐1α) and purine nucleosides adenosine and inosine are critical mediators of physiological responses to acute and chronic hypoxia. The specific aim of this paper was to evaluate the potential role of HIF‐1α in purine‐mediated neuroprotection. We show that adenosine and inosine efficiently rescued clonal rat pheochromocytoma (PC12) cells (up to 43.6%) as well as primary cerebellar granule neurons (up to 25.1%) from hypoxic insult, and furthermore, that HIF‐1α is critical for purine‐mediated neuroprotection. Next, we studied hypoxia or purine nucleoside increased nuclear accumulation of HIF‐1α in PC12 cells. As a possible result of increased protein stabilization or synthesis an up to 2.5‐fold induction of HIF‐1α accumulation was detected. In cerebellar granule neurons, purine nucleosides induced an up to 3.1‐fold HIF‐1α accumulation in cell lysates. Concomitant with these results, small interfering RNA‐mediated reduction of HIF‐1α completely abolished adenosine‐ and inosine‐mediated protection in PC12 cells and severely hampered purine nucleoside‐mediated protection in primary neurons (up to 94.2%). Data presented in this paper thus clearly demonstrate that HIF‐1α is a key regulator of purine nucleoside‐mediated rescue of hypoxic neuronal cells." @default.
• W2169663960 created "2016-06-24" @default.
• W2169663960 creator A5029008554 @default.
• W2169663960 creator A5031306661 @default.
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• W2169663960 date "2008-02-04" @default.
• W2169663960 modified "2023-10-13" @default.
• W2169663960 title "HIF‐1 alpha is an essential effector for purine nucleoside‐mediated neuroprotection against hypoxia in PC12 cells and primary cerebellar granule neurons" @default.
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• W2169663960 doi "https://doi.org/10.1111/j.1471-4159.2008.05275.x" @default.
• W2169663960 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2992945" @default.
• W2169663960 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18248612" @default.
• W2169663960 hasPublicationYear "2008" @default.
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