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- W2169664148 abstract "A remarkable change has occurred in the thinking about epithelial-derived cancer in recent years: From almost entirely focusing on oncogenes and tumor suppressor genes has come the realization that the tumor microenvironment is a coconspirator in the carcinogenic process. Many types of stromal cells, including fibroblasts, adipocytes, macrophages, mast cells, and cells of the vascular system, are crucial contributors to epithelial carcinogenesis. Here, we focus on the fibroblast's role in cancer progression and the molecules involved in the communications between the fibroblasts and the cancer cells, including fibroblast secreted protein 1 (FSP-1 or S100A4), transforming growth factor beta (TGF-beta), the chemokine CXCL-12 (stromal derived factor 1 alpha, SDF-1alpha), type I collagen, and matrix metalloproteinase 13 (MMP-13)." @default.
- W2169664148 created "2016-06-24" @default.
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- W2169664148 creator A5048523154 @default.
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- W2169664148 date "2005-01-01" @default.
- W2169664148 modified "2023-10-15" @default.
- W2169664148 title "The Fibroblastic Coconspirator in Cancer Progression" @default.
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- W2169664148 doi "https://doi.org/10.1101/sqb.2005.70.007" @default.
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