FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169664558> ?p ?o ?g. }

• W2169664558 endingPage "183" @default.
• W2169664558 startingPage "175" @default.
• W2169664558 abstract "Adrenomedullin 2/intermedin (AM2/IMD) is a new member of calcitonin/calcitonin gene-related peptide family. AM is expressed in various tumors including adrenocortical tumors and modulates tumor growth. The AM2/IMD expression has not been studied, however, in adrenal tumors. The expression of AM2/IMD and AM was therefore studied in human adrenal tumors and attached non-neoplastic adrenal tissues by immunocytochemistry (ICC). Immunoreactive (IR)–AM2/IMD was measured by RIA. Furthermore, the expression of AM2/IMD and its receptor components, calcitonin receptor-like receptor (CRLR), and receptor activity-modifying proteins (RAMPs) 1, 2, and 3 mRNA in these tissues was studied by reverse transcription PCR (RT-PCR). ICC showed that AM2/IMD and AM immunoreactivities were localized in adrenocortical tumors and pheochromocytomas. AM2/IMD and AM immunoreactivities were detected in medulla of attached non-neoplastic tissues, while the degree of immunoreactivity for AM2/IMD and AM in cortices of attached adrenals was relatively weak or undetectable. RIA detected IR-AM2/IMD in adrenal tumors (0.414±0.12 to 0.786±0.27 pmol/g wet weight, mean± s.e.m. ) and attached adrenal tissues (0.397±0.052 pmol/g wet weight). Reverse-phase high-performance liquid chromatography showed one broad peak eluted in the similar position to synthetic AM2/IMD with several minor peaks. RT-PCR showed expression of AM2/IMD, CRLR, and RAMP1, RAMP2, and RAMP3 mRNA in tissues of adrenal tumors and attached adrenal glands. In conclusion, AM2/IMD is expressed in human adrenal tumors and attached non-neoplastic adrenal tissues and may play (patho-)physiological roles in normal and neoplastic adrenals as an autocrine/paracrine regulator." @default.
• W2169664558 created "2016-06-24" @default.
• W2169664558 creator A5008308259 @default.
• W2169664558 creator A5012904173 @default.
• W2169664558 creator A5015575554 @default.
• W2169664558 creator A5017829907 @default.
• W2169664558 creator A5027559364 @default.
• W2169664558 creator A5042175811 @default.
• W2169664558 creator A5066495888 @default.
• W2169664558 creator A5080059055 @default.
• W2169664558 creator A5080725230 @default.
• W2169664558 creator A5085235219 @default.
• W2169664558 creator A5091608515 @default.
• W2169664558 date "2008-05-06" @default.
• W2169664558 modified "2023-09-30" @default.
• W2169664558 title "Expression of adrenomedullin 2/intermedin in human adrenal tumors and attached non-neoplastic adrenal tissues" @default.
• W2169664558 cites W1582895919 @default.
• W2169664558 cites W1965018863 @default.
• W2169664558 cites W1983283095 @default.
• W2169664558 cites W1985833604 @default.
• W2169664558 cites W1989419353 @default.
• W2169664558 cites W1998767386 @default.
• W2169664558 cites W2009793291 @default.
• W2169664558 cites W2009795654 @default.
• W2169664558 cites W2015548817 @default.
• W2169664558 cites W2016414924 @default.
• W2169664558 cites W2023370041 @default.
• W2169664558 cites W2033665745 @default.
• W2169664558 cites W2039836243 @default.
• W2169664558 cites W2040887234 @default.
• W2169664558 cites W2041700818 @default.
• W2169664558 cites W2044285853 @default.
• W2169664558 cites W2052871793 @default.
• W2169664558 cites W2055474153 @default.
• W2169664558 cites W2056833940 @default.
• W2169664558 cites W2069207287 @default.
• W2169664558 cites W2073616552 @default.
• W2169664558 cites W2075900728 @default.
• W2169664558 cites W2082063347 @default.
• W2169664558 cites W2084957546 @default.
• W2169664558 cites W2086889806 @default.
• W2169664558 cites W2086930952 @default.
• W2169664558 cites W2093649032 @default.
• W2169664558 cites W2102237706 @default.
• W2169664558 cites W2104583114 @default.
• W2169664558 cites W2143424314 @default.
• W2169664558 cites W2146182395 @default.
• W2169664558 cites W2164577358 @default.
• W2169664558 cites W2171823263 @default.
• W2169664558 cites W225639417 @default.
• W2169664558 cites W2317100079 @default.
• W2169664558 cites W2331943761 @default.
• W2169664558 doi "https://doi.org/10.1677/joe-08-0103" @default.
• W2169664558 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18460550" @default.
• W2169664558 hasPublicationYear "2008" @default.
• W2169664558 type Work @default.
• W2169664558 sameAs 2169664558 @default.
• W2169664558 citedByCount "24" @default.
• W2169664558 countsByYear W21696645582012 @default.
• W2169664558 countsByYear W21696645582013 @default.
• W2169664558 countsByYear W21696645582014 @default.
• W2169664558 countsByYear W21696645582015 @default.
• W2169664558 countsByYear W21696645582018 @default.
• W2169664558 countsByYear W21696645582019 @default.
• W2169664558 countsByYear W21696645582021 @default.
• W2169664558 countsByYear W21696645582022 @default.
• W2169664558 countsByYear W21696645582023 @default.
• W2169664558 crossrefType "journal-article" @default.
• W2169664558 hasAuthorship W2169664558A5008308259 @default.
• W2169664558 hasAuthorship W2169664558A5012904173 @default.
• W2169664558 hasAuthorship W2169664558A5015575554 @default.
• W2169664558 hasAuthorship W2169664558A5017829907 @default.
• W2169664558 hasAuthorship W2169664558A5027559364 @default.
• W2169664558 hasAuthorship W2169664558A5042175811 @default.
• W2169664558 hasAuthorship W2169664558A5066495888 @default.
• W2169664558 hasAuthorship W2169664558A5080059055 @default.
• W2169664558 hasAuthorship W2169664558A5080725230 @default.
• W2169664558 hasAuthorship W2169664558A5085235219 @default.
• W2169664558 hasAuthorship W2169664558A5091608515 @default.
• W2169664558 hasBestOaLocation W21696645581 @default.
• W2169664558 hasConcept C118303440 @default.
• W2169664558 hasConcept C126322002 @default.
• W2169664558 hasConcept C134018914 @default.
• W2169664558 hasConcept C163170386 @default.
• W2169664558 hasConcept C170493617 @default.
• W2169664558 hasConcept C185592680 @default.
• W2169664558 hasConcept C2777152744 @default.
• W2169664558 hasConcept C2777977426 @default.
• W2169664558 hasConcept C2779627488 @default.
• W2169664558 hasConcept C2780694816 @default.
• W2169664558 hasConcept C71924100 @default.
• W2169664558 hasConcept C86803240 @default.
• W2169664558 hasConceptScore W2169664558C118303440 @default.
• W2169664558 hasConceptScore W2169664558C126322002 @default.
• W2169664558 hasConceptScore W2169664558C134018914 @default.
• W2169664558 hasConceptScore W2169664558C163170386 @default.
• W2169664558 hasConceptScore W2169664558C170493617 @default.
• W2169664558 hasConceptScore W2169664558C185592680 @default.

• next