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- W2169666102 abstract "The present study deals with investigating the effects of diabetes and gliclazide –treatment on liver and pancreatic islet β -cell of mother rats and to explain susceptibility of the mentioned organs of their pups as well as of the disease progress. Thirty-six pregnant rats were arranged into four groups (n=9), including control, gliclazide-treatment, diabetic and diabetic receiving gliclazide-treatment. Experimental induction of the diabetes was carried out by intraperitoneal (i.p.) of single dose of 60 mg streptozotocin /kg body weight at 6 th day of gestation. Oral administration of gliclazide (5.2 mg/kg body weight) was done every other day from 6 th day of gestation until parturition. At parturition, the mother rats were euthanized and liver and pancreas specimens were harvested and prepared for light transmission electron microscopy (TEM). The observed findings revealed liver & islet dysfunction in pregnant mother and their pups. Gliclazide –treatment ameliorated the hepatic and pancreatic picture at the light and ultrastructural level. However, mild hepatitis and degranulation of secretory granules of β-cells were still existed. The authors concluded that both maternal diabetes, and their pups were influenced by hepatitis and degranulation of islets β-cells. Gliclazide-treatment showed a sign of amelioration of the liver and pancreatic disease of mother rats and their pups." @default.
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- W2169666102 date "2013-01-01" @default.
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- W2169666102 title "Effects of Experimental Diabetes and Gliclazide on Pregnant Albino Rats and Their Pups" @default.
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