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• W2169667942 abstract "We conducted this prospective study to expand available information in relation to serum phosphate levels in treatment of acute asthma. A β-adrenergic agonist, salbutamol, was used for this purpose. Twenty-six patients who met the inclusion criteria as; age over 16 years, asthma history, and an acute exacerbation were included. Serum blood urea nitrogen, creatinine, glucose were within normal limits in all the patients. None of the patients were on chronic theophylline therapy. Baseline serum phosphate and potassium levels were measured. Nebulized salbutamol (2.5 mg) was used three times at every hour. After 60 min, serum phosphate and potassium levels were measured. Serum phosphate levels decreased from 3.7 ± 0.9 mg/dL (baseline) to 3.6±0.9 mg/dL at 60 min. This decrease was not statistically significant (p = 0.373). Serum potassium levels decreased significantly (p < 0.001) from 4.6 ± 0.7 mmol/L (baseline) to 4.3 ± 0.7 mmol/L (60 min). Administration of nebulized salbutamol during the emergency treatment of acute exacerbation of asthma is not associated with a statistical decrease in serum phosphate. There was significant hypokalemia. This study indicates that a further study is needed to elucidate the clinical significance of nebulized salbutamol on serum phosphate. Levámos a cabo este estudo prospetivo para ampliar a informação disponível relativamente aos níveis de fosfato sérico no tratamento de asma aguda. Foi utilizado um agonista β-adrenérgico, salbutamol, para este efeito. Foram incluídos 26 doentes que cumpriam os critérios de inclusão de: idade superior a 16 anos, história de asma, incluindo uma exacerbação aguda. A ureia do soro sanguíneo, creatinina e glucose estavam nos limites normais em todos os doentes. Nenhum dos doentes era submetido a terapia crónica de teofilina. Os níveis da base de referência de fosfato e potássio sérico foram medidos. O nebulizador de salbutamol (2,5 mg) era usado 3 vezes por hora. Após 60 min, os níveis da base de referência de fosfato e potássio sérico eram medidos. Os níveis de fosfato sérico diminuíram de 3,7 ± 0,9 mg/dL (base de referência) para 3,6 ± 0,9 mg/dL aos 60 min. Esta redução não era estatisticamente significativa (p = 0,373). Os níveis de potássio sérico diminuíram significativamente (p < 0,001) de 4,6 ± 0,7 mmol/L (base de referência) para 4,3 ± 0,7 mmol/L aos 60 min. A administração de salbutamol nebulizado durante o tratamento de urgência de uma exacerbação aguda de asma não está associada a uma diminuição estatística do fosfato sérico. Ocorreu uma hipocalemia significativa. Este estudo indica que é necessário um estudo adicional para esclarecer o significado clínico do salbutamol nebulizado no fosfato sérico." @default.
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• W2169667942 date "2013-09-01" @default.
• W2169667942 modified "2023-10-02" @default.
• W2169667942 title "Nebulized salbutamol for asthma: Effects on serum potassium and phosphate levels at the 60min" @default.
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• W2169667942 doi "https://doi.org/10.1016/j.rppneu.2012.12.003" @default.
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