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- W2169670248 endingPage "S11" @default.
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- W2169670248 abstract "In many parkinsonian syndromes, neuromelanin (NM)-containing dopaminergic neurons of the substantia nigra (SN) are selectively targeted by the noxius pathogens. Studies of the constitutional and functional features of human NM allow the formulation of a logical hypothesis on its role in parkinsonian syndromes. In the early stages, NM synthesis and iron-chelating properties may act as a powerful protective mechanism, delaying symptom appearance and/or slowing disease progression. Once these systems have been exhausted, the pathogenic mechanisms affecting cytoplasmic organelles other than NM destroy NM-harboring neurons, with consequent pouring out of NM granules. These in turn activate microglia, causing release of nitric oxide, interleukin-6 and tumor necrosis factor-α, thus becoming an important determinant of disease aggravation. Neuromelanin appears to be a suitable target for devising chemical agents that might modify the course of these diseases." @default.
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- W2169670248 date "2006-10-09" @default.
- W2169670248 modified "2023-09-25" @default.
- W2169670248 title "A proposed dual role of neuromelanin in the pathogenesis of Parkinson's disease" @default.
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- W2169670248 doi "https://doi.org/10.1212/wnl.67.7_suppl_2.s8" @default.
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