FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169671503> ?p ?o ?g. }

• W2169671503 endingPage "721" @default.
• W2169671503 startingPage "711" @default.
• W2169671503 abstract "The mechanism by which classical cadherins mediate cell adhesion and, in particular, the roles played by calcium and Trp2, the second amino acid in the N-terminal domain, have long been controversial. We have used antibodies to investigate the respective contributions of Trp2 and calcium to the stability of the N-terminal domain of N-cadherin. Using a peptide antibody to the βB strand in domain 1, which detects a disordered structure, we show that both Trp2 and calcium play crucial parts in regulating stability of the domain. The epitope for another antibody, mAb GC4, has been mapped to the base of domain 1. Binding of GC4 to this epitope was shown to depend on intramolecular `docking' of Trp2 into the domain 1 structure. Using this property, we provide evidence that calcium regulates a dynamic equilibrium between docked and undocked Trp2. Finally, a novel technique has been developed to test whether Trp2 cross-intercalation between cadherin molecules from adjacent cells (strand exchange) is central to cadherin-mediated cell adhesion. Guided by crystal structures showing strand exchange, we have introduced single cysteine point mutations into N-cadherin domain 1 in such a way that a disulphide bond will form between opposing N-cadherin molecules during cell adhesion if strand exchange occurs. The bond requires complementary cysteines to be precisely juxtaposed according to the strand exchange model. Our results demonstrate that the disulphide bond forms as predicted. This provides compelling evidence that strand exchange is indeed a primary event in cell adhesion by classical cadherins." @default.
• W2169671503 created "2016-06-24" @default.
• W2169671503 creator A5020955546 @default.
• W2169671503 creator A5024814212 @default.
• W2169671503 creator A5051353353 @default.
• W2169671503 creator A5082117837 @default.
• W2169671503 date "2005-02-15" @default.
• W2169671503 modified "2023-10-04" @default.
• W2169671503 title "The mechanism of cell adhesion by classical cadherins: the role of domain 1" @default.
• W2169671503 cites W1824211826 @default.
• W2169671503 cites W1906438547 @default.
• W2169671503 cites W1964597029 @default.
• W2169671503 cites W1967372848 @default.
• W2169671503 cites W1967532587 @default.
• W2169671503 cites W1978609854 @default.
• W2169671503 cites W1979968104 @default.
• W2169671503 cites W1983745506 @default.
• W2169671503 cites W1987824814 @default.
• W2169671503 cites W1991193202 @default.
• W2169671503 cites W1995855524 @default.
• W2169671503 cites W1999611104 @default.
• W2169671503 cites W1999630903 @default.
• W2169671503 cites W2000132958 @default.
• W2169671503 cites W2018842202 @default.
• W2169671503 cites W2019496511 @default.
• W2169671503 cites W2020514343 @default.
• W2169671503 cites W2022087383 @default.
• W2169671503 cites W2025234475 @default.
• W2169671503 cites W2034731135 @default.
• W2169671503 cites W2035323213 @default.
• W2169671503 cites W2039569400 @default.
• W2169671503 cites W2041905284 @default.
• W2169671503 cites W2048076819 @default.
• W2169671503 cites W2055472128 @default.
• W2169671503 cites W2075574902 @default.
• W2169671503 cites W2088877495 @default.
• W2169671503 cites W2089714150 @default.
• W2169671503 cites W2092051268 @default.
• W2169671503 cites W2092992943 @default.
• W2169671503 cites W2107976817 @default.
• W2169671503 cites W2110075127 @default.
• W2169671503 cites W2115956021 @default.
• W2169671503 cites W2122758516 @default.
• W2169671503 cites W2143759076 @default.
• W2169671503 cites W2145810425 @default.
• W2169671503 cites W2152802507 @default.
• W2169671503 cites W2159624278 @default.
• W2169671503 cites W2165652396 @default.
• W2169671503 cites W2242263946 @default.
• W2169671503 cites W307287215 @default.
• W2169671503 cites W4299936915 @default.
• W2169671503 cites W48910532 @default.
• W2169671503 doi "https://doi.org/10.1242/jcs.01665" @default.
• W2169671503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15671061" @default.
• W2169671503 hasPublicationYear "2005" @default.
• W2169671503 type Work @default.
• W2169671503 sameAs 2169671503 @default.
• W2169671503 citedByCount "42" @default.
• W2169671503 countsByYear W21696715032012 @default.
• W2169671503 countsByYear W21696715032013 @default.
• W2169671503 countsByYear W21696715032014 @default.
• W2169671503 countsByYear W21696715032015 @default.
• W2169671503 countsByYear W21696715032016 @default.
• W2169671503 countsByYear W21696715032017 @default.
• W2169671503 countsByYear W21696715032018 @default.
• W2169671503 countsByYear W21696715032019 @default.
• W2169671503 countsByYear W21696715032020 @default.
• W2169671503 crossrefType "journal-article" @default.
• W2169671503 hasAuthorship W2169671503A5020955546 @default.
• W2169671503 hasAuthorship W2169671503A5024814212 @default.
• W2169671503 hasAuthorship W2169671503A5051353353 @default.
• W2169671503 hasAuthorship W2169671503A5082117837 @default.
• W2169671503 hasConcept C12554922 @default.
• W2169671503 hasConcept C1491633281 @default.
• W2169671503 hasConcept C149402561 @default.
• W2169671503 hasConcept C159110408 @default.
• W2169671503 hasConcept C159654299 @default.
• W2169671503 hasConcept C195616568 @default.
• W2169671503 hasConcept C41685203 @default.
• W2169671503 hasConcept C54355233 @default.
• W2169671503 hasConcept C55493867 @default.
• W2169671503 hasConcept C71924100 @default.
• W2169671503 hasConcept C85789140 @default.
• W2169671503 hasConcept C86803240 @default.
• W2169671503 hasConceptScore W2169671503C12554922 @default.
• W2169671503 hasConceptScore W2169671503C1491633281 @default.
• W2169671503 hasConceptScore W2169671503C149402561 @default.
• W2169671503 hasConceptScore W2169671503C159110408 @default.
• W2169671503 hasConceptScore W2169671503C159654299 @default.
• W2169671503 hasConceptScore W2169671503C195616568 @default.
• W2169671503 hasConceptScore W2169671503C41685203 @default.
• W2169671503 hasConceptScore W2169671503C54355233 @default.
• W2169671503 hasConceptScore W2169671503C55493867 @default.
• W2169671503 hasConceptScore W2169671503C71924100 @default.
• W2169671503 hasConceptScore W2169671503C85789140 @default.
• W2169671503 hasConceptScore W2169671503C86803240 @default.
• W2169671503 hasIssue "4" @default.
• W2169671503 hasLocation W21696715031 @default.

• next