FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169690377> ?p ?o ?g. }

• W2169690377 endingPage "128" @default.
• W2169690377 startingPage "124" @default.
• W2169690377 abstract "Cyclic nucleotide Phosphodiesterases (PDEs) are ubiquitously distributed in mammalian tissues and play a major role in cell signaling by hydrolyzing cyclic Adenosine Monophosphate (cAMP) and cyclic Guanosine Monophosphate (cGMP). Impairments in signal transduction have been implicated as possible mechanism of reduced plasticity and neuronal survival in major depressive disorders. PDE inhibitors possess a potentially powerful means to manipulate secondary messengers involved in learning, memory and mood. Cilostazol is an antiplatelet agent indicated for the treatment of intermittent claudication with peripheral artery occlusion and for the prevention of ischemic stroke worldwide. Various animal studies have reported neuroprotective, anti apoptotic, cognition and cerebral blood flow improvement properties of cilostazol.In this study, the antidepressant and anxiolytic effects of cilostazol were evaluated in mice using behavioral tests sensitive to clinically effective antidepressant compound.Cilostazol, administered intraperitoneally (20 mg/kg), decreased immobility time of mice when subjected to forced swim test and tail suspension test as compared to standard fluoxetine (20 mg/kg). Cilostazol also produced significant decrease in the number of marbles buried as compared to fluoxetine in marble burying model.The present study suggests that cilostazol possesses potential antidepressant and anxiolytic activity, which could be of therapeutic interest for use in patients with depressive disorders." @default.
• W2169690377 created "2016-06-24" @default.
• W2169690377 creator A5015900828 @default.
• W2169690377 creator A5041423887 @default.
• W2169690377 creator A5050637450 @default.
• W2169690377 date "2012-04-01" @default.
• W2169690377 modified "2023-09-24" @default.
• W2169690377 title "Evaluation of Antidepressant and Anxiolytic Activity of Phosphodiesterase 3 Inhibitor - Cilostazol" @default.
• W2169690377 cites W1963772921 @default.
• W2169690377 cites W1966707642 @default.
• W2169690377 cites W1977096084 @default.
• W2169690377 cites W1979687697 @default.
• W2169690377 cites W1982627896 @default.
• W2169690377 cites W1991283322 @default.
• W2169690377 cites W1995986656 @default.
• W2169690377 cites W1997451914 @default.
• W2169690377 cites W2000104976 @default.
• W2169690377 cites W2004436130 @default.
• W2169690377 cites W2005594217 @default.
• W2169690377 cites W2022584533 @default.
• W2169690377 cites W2023920385 @default.
• W2169690377 cites W2029299795 @default.
• W2169690377 cites W2032985357 @default.
• W2169690377 cites W2053714798 @default.
• W2169690377 cites W2065210815 @default.
• W2169690377 cites W2089299823 @default.
• W2169690377 cites W2099768282 @default.
• W2169690377 cites W2107034951 @default.
• W2169690377 cites W2125939610 @default.
• W2169690377 cites W2152523192 @default.
• W2169690377 cites W29240549 @default.
• W2169690377 cites W25832532 @default.
• W2169690377 doi "https://doi.org/10.4103/0253-7176.101776" @default.
• W2169690377 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3498773" @default.
• W2169690377 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23162186" @default.
• W2169690377 hasPublicationYear "2012" @default.
• W2169690377 type Work @default.
• W2169690377 sameAs 2169690377 @default.
• W2169690377 citedByCount "14" @default.
• W2169690377 countsByYear W21696903772013 @default.
• W2169690377 countsByYear W21696903772014 @default.
• W2169690377 countsByYear W21696903772015 @default.
• W2169690377 countsByYear W21696903772016 @default.
• W2169690377 countsByYear W21696903772018 @default.
• W2169690377 countsByYear W21696903772019 @default.
• W2169690377 countsByYear W21696903772021 @default.
• W2169690377 countsByYear W21696903772022 @default.
• W2169690377 countsByYear W21696903772023 @default.
• W2169690377 crossrefType "journal-article" @default.
• W2169690377 hasAuthorship W2169690377A5015900828 @default.
• W2169690377 hasAuthorship W2169690377A5041423887 @default.
• W2169690377 hasAuthorship W2169690377A5050637450 @default.
• W2169690377 hasBestOaLocation W21696903772 @default.
• W2169690377 hasConcept C126322002 @default.
• W2169690377 hasConcept C136569192 @default.
• W2169690377 hasConcept C170493617 @default.
• W2169690377 hasConcept C181199279 @default.
• W2169690377 hasConcept C185592680 @default.
• W2169690377 hasConcept C25498285 @default.
• W2169690377 hasConcept C2775864247 @default.
• W2169690377 hasConcept C2776134451 @default.
• W2169690377 hasConcept C2776668983 @default.
• W2169690377 hasConcept C2776766087 @default.
• W2169690377 hasConcept C2777628954 @default.
• W2169690377 hasConcept C2777765862 @default.
• W2169690377 hasConcept C2779177272 @default.
• W2169690377 hasConcept C2779820409 @default.
• W2169690377 hasConcept C2780994212 @default.
• W2169690377 hasConcept C2781001258 @default.
• W2169690377 hasConcept C2781161787 @default.
• W2169690377 hasConcept C519581460 @default.
• W2169690377 hasConcept C55493867 @default.
• W2169690377 hasConcept C58141971 @default.
• W2169690377 hasConcept C62826618 @default.
• W2169690377 hasConcept C71924100 @default.
• W2169690377 hasConcept C98274493 @default.
• W2169690377 hasConceptScore W2169690377C126322002 @default.
• W2169690377 hasConceptScore W2169690377C136569192 @default.
• W2169690377 hasConceptScore W2169690377C170493617 @default.
• W2169690377 hasConceptScore W2169690377C181199279 @default.
• W2169690377 hasConceptScore W2169690377C185592680 @default.
• W2169690377 hasConceptScore W2169690377C25498285 @default.
• W2169690377 hasConceptScore W2169690377C2775864247 @default.
• W2169690377 hasConceptScore W2169690377C2776134451 @default.
• W2169690377 hasConceptScore W2169690377C2776668983 @default.
• W2169690377 hasConceptScore W2169690377C2776766087 @default.
• W2169690377 hasConceptScore W2169690377C2777628954 @default.
• W2169690377 hasConceptScore W2169690377C2777765862 @default.
• W2169690377 hasConceptScore W2169690377C2779177272 @default.
• W2169690377 hasConceptScore W2169690377C2779820409 @default.
• W2169690377 hasConceptScore W2169690377C2780994212 @default.
• W2169690377 hasConceptScore W2169690377C2781001258 @default.
• W2169690377 hasConceptScore W2169690377C2781161787 @default.
• W2169690377 hasConceptScore W2169690377C519581460 @default.
• W2169690377 hasConceptScore W2169690377C55493867 @default.
• W2169690377 hasConceptScore W2169690377C58141971 @default.
• W2169690377 hasConceptScore W2169690377C62826618 @default.
• W2169690377 hasConceptScore W2169690377C71924100 @default.

• next