FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169692682> ?p ?o ?g. }

• W2169692682 endingPage "5" @default.
• W2169692682 startingPage "4250" @default.
• W2169692682 abstract "Summary The incorporation of [ 3 H]fucose into glycoproteins of Sarcoma 180 cells in vitro was decreased within 2 hr of exposure to 6-thioguanine (6-TG); 50% inhibition was produced by 8 µm 6-TG. Under identical conditions, no decrease in [ 3 H]glucosamine incorporation into acid-insoluble material was detected. Similarly, [ 3 H]fucose incorporation, but not [ 14 C]glucosamine incorporation into glycoproteins of Sarcoma 180 ascites cells in vivo , was significantly reduced 1 to 6 hr after 6-TG treatment (20 mg/kg) of mice bearing 6-day implants of this neoplasm; the maximum depression of fucose utilization occurred at 2 hr after drug treatment. The decrease in [ 3 H]fucose incorporation into glycoprotein was dose dependent and reached a maximum reduction of 77% of control incorporation 2 hr after 6-TG (10 mg/kg). The radioactivity from fucose found in acid-soluble extracts of Sarcoma 180 cells was decreased by 45% after 6-TG (10 mg/kg). In contrast, this concentration of 6-TG did not decrease the level of radioactivity from [ 3 H]fucose found in acid-soluble extracts of a subline of Sarcoma 180 resistant to 6-TG and produced only a 38% decrease in fucose incorporation into the acid-insoluble fraction of this neoplasm. The inhibition of [ 3 H]fucose incorporation into glycoproteins of Sarcoma 180 produced by 6-TG appeared to be due to a drug-induced decrease in the formation of guanosine diphosphate-[ 3 H]fucose and a concomitant decrease in the intracellular content of guanosine diphosphate-fucose. These data suggest that 6-TG exerts, as a metabolic lesion, a suppression of guanine nucleotide sugar biosynthesis. Since fucose is largely a terminal carbohydrate of glycoproteins and glycolipids of the plasma membrane, 6-TG may alter membrane composition. This phenomenon may be associated with the cytotoxicity of 6-TG to neoplastic cells." @default.
• W2169692682 created "2016-06-24" @default.
• W2169692682 creator A5025310836 @default.
• W2169692682 creator A5043512123 @default.
• W2169692682 creator A5085858115 @default.
• W2169692682 date "1977-12-01" @default.
• W2169692682 modified "2023-09-23" @default.
• W2169692682 title "Inhibition of L-fucose incorporation into glycoprotein of Sarcoma 180 ascites cells by 6-thioguanine." @default.
• W2169692682 cites W145440350 @default.
• W2169692682 cites W1501822391 @default.
• W2169692682 cites W1510948506 @default.
• W2169692682 cites W1529180858 @default.
• W2169692682 cites W1539061345 @default.
• W2169692682 cites W1543578340 @default.
• W2169692682 cites W1559260484 @default.
• W2169692682 cites W1592375687 @default.
• W2169692682 cites W1928250650 @default.
• W2169692682 cites W1990269940 @default.
• W2169692682 cites W1993344738 @default.
• W2169692682 cites W2016476983 @default.
• W2169692682 cites W2039160358 @default.
• W2169692682 cites W2045500852 @default.
• W2169692682 cites W2052318454 @default.
• W2169692682 cites W2056975543 @default.
• W2169692682 cites W2074442869 @default.
• W2169692682 cites W2093384063 @default.
• W2169692682 cites W2108324497 @default.
• W2169692682 cites W2112945329 @default.
• W2169692682 cites W2125407450 @default.
• W2169692682 cites W2203146963 @default.
• W2169692682 cites W64445091 @default.
• W2169692682 cites W70324109 @default.
• W2169692682 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/922719" @default.
• W2169692682 hasPublicationYear "1977" @default.
• W2169692682 type Work @default.
• W2169692682 sameAs 2169692682 @default.
• W2169692682 citedByCount "5" @default.
• W2169692682 crossrefType "journal-article" @default.
• W2169692682 hasAuthorship W2169692682A5025310836 @default.
• W2169692682 hasAuthorship W2169692682A5043512123 @default.
• W2169692682 hasAuthorship W2169692682A5085858115 @default.
• W2169692682 hasConcept C108625454 @default.
• W2169692682 hasConcept C150903083 @default.
• W2169692682 hasConcept C185592680 @default.
• W2169692682 hasConcept C202751555 @default.
• W2169692682 hasConcept C207001950 @default.
• W2169692682 hasConcept C2776841590 @default.
• W2169692682 hasConcept C2777995097 @default.
• W2169692682 hasConcept C2778125326 @default.
• W2169692682 hasConcept C55493867 @default.
• W2169692682 hasConcept C86803240 @default.
• W2169692682 hasConceptScore W2169692682C108625454 @default.
• W2169692682 hasConceptScore W2169692682C150903083 @default.
• W2169692682 hasConceptScore W2169692682C185592680 @default.
• W2169692682 hasConceptScore W2169692682C202751555 @default.
• W2169692682 hasConceptScore W2169692682C207001950 @default.
• W2169692682 hasConceptScore W2169692682C2776841590 @default.
• W2169692682 hasConceptScore W2169692682C2777995097 @default.
• W2169692682 hasConceptScore W2169692682C2778125326 @default.
• W2169692682 hasConceptScore W2169692682C55493867 @default.
• W2169692682 hasConceptScore W2169692682C86803240 @default.
• W2169692682 hasIssue "12" @default.
• W2169692682 hasLocation W21696926821 @default.
• W2169692682 hasOpenAccess W2169692682 @default.
• W2169692682 hasPrimaryLocation W21696926821 @default.
• W2169692682 hasRelatedWork W1501822391 @default.
• W2169692682 hasRelatedWork W2008244788 @default.
• W2169692682 hasRelatedWork W201474726 @default.
• W2169692682 hasRelatedWork W2029686515 @default.
• W2169692682 hasRelatedWork W2038494399 @default.
• W2169692682 hasRelatedWork W2087733961 @default.
• W2169692682 hasRelatedWork W2088578433 @default.
• W2169692682 hasRelatedWork W2165233066 @default.
• W2169692682 hasRelatedWork W2314217051 @default.
• W2169692682 hasRelatedWork W3023695257 @default.
• W2169692682 hasVolume "37" @default.
• W2169692682 isParatext "false" @default.
• W2169692682 isRetracted "false" @default.
• W2169692682 magId "2169692682" @default.
• W2169692682 workType "article" @default.