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- W2169704715 abstract "The diverse antigen receptor repertoires of B and T lymphocytes are generated by somatic rearrangement of Ig and TCR V, D, and J gene segments during lymphocyte development. A basic mechanistic understanding of V(D)J recombination reaction is now at hand. The process is initiated by recombinase proteins recombination activating gene (RAG)-1 and RAG-2, which bind to recombination signal sequences (RSSs) that flank Ig and TCR gene segments, recruit a pair of RSSs into a synaptic complex, and generate double strand breaks (DSBs) between the RSSs and coding segments. The reaction is then completed with the additional participation of DSB repair proteins, which help to process and rejoin the coding and signal end molecules to generate coding joints and signal joints, respectively. V(D)J recombination at the various Ig and TCR loci is highly regulated during lymphocyte development, with lineage- and developmental stage‐specific rearrangement events distinguishing individual loci, and even individual gene segments within loci. It has long been appreciated that this developmental regulation cannot be accounted for by the expression of either RAG or DNA repair proteins. It has been noted that transcription of unrearranged gene segments (germline transcription) parallels their developmental activation for V(D)J recombination. Yancopoulos and Alt interpreted this transcriptional activity to reflect a permis" @default.
- W2169704715 created "2016-06-24" @default.
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- W2169704715 date "2001-04-02" @default.
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- W2169704715 title "V(D)j Recombination Becomes Accessible" @default.
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- W2169704715 doi "https://doi.org/10.1084/jem.193.7.f27" @default.
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