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• W2169705384 startingPage "2554" @default.
• W2169705384 abstract "ABSTRACT Strain AM-19226 is a pathogenic non-O1/non-O139 serogroup Vibrio cholerae strain that does not encode the toxin-coregulated pilus or cholera toxin but instead causes disease using a type three secretion system (T3SS). Two genes within the T3SS pathogenicity island, herein named vttR A (locus tag A33_1664) and vttR B (locus tag A33_1675), are predicted to encode proteins that show similarity to the transcriptional regulator ToxR, which is found in all strains of V. cholerae . Strains with a deletion of vttR A or vttR B showed attenuated colonization in vivo , indicating that the T3SS-encoded regulatory proteins play a role in virulence. lacZ transcriptional reporter fusions to intergenic regions upstream of genes encoding the T3SS structural components identified growth in the presence of bile as a condition that modulates gene expression. Under this condition, VttR A and VttR B were necessary for maximal gene expression. In contrast, growth in bile did not substantially alter the expression of a reporter fusion to the vopF gene, which encodes an effector protein. Increased vttR B reporter fusion activity was observed in a Δ vttR B strain background, suggesting that VttR B may regulate its own expression. The collective results are consistent with the hypothesis that T3SS-encoded regulatory proteins are essential for pathogenesis and control the expression of selected T3SS genes." @default.
• W2169705384 created "2016-06-24" @default.
• W2169705384 creator A5021969411 @default.
• W2169705384 creator A5047832916 @default.
• W2169705384 creator A5077333072 @default.
• W2169705384 creator A5089546452 @default.
• W2169705384 date "2010-06-01" @default.
• W2169705384 modified "2023-10-14" @default.
• W2169705384 title "<i>vttR</i> _A and <i>vttR</i> _B Encode ToxR Family Proteins That Mediate Bile-Induced Expression of Type Three Secretion System Genes in a Non-O1/Non-O139 <i>Vibrio cholerae</i> Strain" @default.
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• W2169705384 doi "https://doi.org/10.1128/iai.01073-09" @default.
• W2169705384 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2876560" @default.
• W2169705384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20385759" @default.
• W2169705384 hasPublicationYear "2010" @default.
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