FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169711067> ?p ?o ?g. }

• W2169711067 endingPage "e49767" @default.
• W2169711067 startingPage "e49767" @default.
• W2169711067 abstract "Mast cells are hematopoietically-derived tissue immune cells that participate in acquired and innate immunity, as well as in inflammation through release of many chemokines and cytokines, especially in response to the pro-inflammatory peptide substance P (SP). Inflammation is critical in the pathogenesis of many diseases, but the trigger(s) is often unknown. We investigated if mast cell stimulation leads to secretion of mitochondrial components and whether these could elicit autocrine and/or paracrine inflammatory effects. Here we show that human LAD2 mast cells stimulated by IgE/anti-IgE or by the SP led to secretion of mitochondrial particles, mitochondrial (mt) mtDNA and ATP without cell death. Mitochondria purified fromLAD2 cells and, when mitochondria added to mast cells trigger degranulation and release of histamine, PGD2, IL-8, TNF, and IL-1β. This stimulatory effect is partially inhibited by an ATP receptor antagonist and by DNAse. These results suggest that the mitochondrial protein fraction may also contribute. Purified mitochondria also stimulate IL-8 and vascular endothelial growth factor (VEGF) release from cultured human keratinocytes, and VEGF release from primary human microvascular endothelial cells. In order to investigate if mitochondrial components could be secreted in vivo, we injected rats intraperiotoneally (ip) with compound 48/80, which mimicks the action of SP. Peritoneal mast cells degranulated and mitochondrial particles were documented by transimission electron microscopy outside the cells. We also wished to investigate if mitochondrial components secreted locally could reach the systemic circulation. Administration ip of mtDNA isolated from LAD2 cells in rats was detected in their serum within 4 hr, indicating that extravascular mtDNA could enter the systemic circulation. Secretion of mitochondrial components from stimulated live mast cells may act as “autopathogens” contributing to the pathogenesis of inflammatory diseases and may be used as targets for novel treatments." @default.
• W2169711067 created "2016-06-24" @default.
• W2169711067 creator A5017044001 @default.
• W2169711067 creator A5040411204 @default.
• W2169711067 creator A5065245949 @default.
• W2169711067 creator A5078194805 @default.
• W2169711067 creator A5085356549 @default.
• W2169711067 date "2012-12-17" @default.
• W2169711067 modified "2023-09-27" @default.
• W2169711067 title "Stimulated Human Mast Cells Secrete Mitochondrial Components That Have Autocrine and Paracrine Inflammatory Actions" @default.
• W2169711067 cites W1495825745 @default.
• W2169711067 cites W1586878534 @default.
• W2169711067 cites W1639310471 @default.
• W2169711067 cites W1916478001 @default.
• W2169711067 cites W1960998321 @default.
• W2169711067 cites W1965010109 @default.
• W2169711067 cites W1968789597 @default.
• W2169711067 cites W1971977052 @default.
• W2169711067 cites W1978980985 @default.
• W2169711067 cites W1979278210 @default.
• W2169711067 cites W1992153206 @default.
• W2169711067 cites W1992322823 @default.
• W2169711067 cites W1993091864 @default.
• W2169711067 cites W1995864156 @default.
• W2169711067 cites W1998783767 @default.
• W2169711067 cites W2000528910 @default.
• W2169711067 cites W2003140193 @default.
• W2169711067 cites W2023542615 @default.
• W2169711067 cites W2029821423 @default.
• W2169711067 cites W2043992563 @default.
• W2169711067 cites W2050601356 @default.
• W2169711067 cites W2062746439 @default.
• W2169711067 cites W2086722873 @default.
• W2169711067 cites W2090466136 @default.
• W2169711067 cites W2094438673 @default.
• W2169711067 cites W2096349085 @default.
• W2169711067 cites W2096663326 @default.
• W2169711067 cites W2105754268 @default.
• W2169711067 cites W2107063100 @default.
• W2169711067 cites W2107413005 @default.
• W2169711067 cites W2114305100 @default.
• W2169711067 cites W2134219545 @default.
• W2169711067 cites W2139695498 @default.
• W2169711067 cites W2147572829 @default.
• W2169711067 cites W2150594596 @default.
• W2169711067 cites W2163825591 @default.
• W2169711067 doi "https://doi.org/10.1371/journal.pone.0049767" @default.
• W2169711067 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3524249" @default.
• W2169711067 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23284625" @default.
• W2169711067 hasPublicationYear "2012" @default.
• W2169711067 type Work @default.
• W2169711067 sameAs 2169711067 @default.
• W2169711067 citedByCount "92" @default.
• W2169711067 countsByYear W21697110672013 @default.
• W2169711067 countsByYear W21697110672014 @default.
• W2169711067 countsByYear W21697110672015 @default.
• W2169711067 countsByYear W21697110672016 @default.
• W2169711067 countsByYear W21697110672017 @default.
• W2169711067 countsByYear W21697110672018 @default.
• W2169711067 countsByYear W21697110672019 @default.
• W2169711067 countsByYear W21697110672020 @default.
• W2169711067 countsByYear W21697110672021 @default.
• W2169711067 countsByYear W21697110672022 @default.
• W2169711067 countsByYear W21697110672023 @default.
• W2169711067 crossrefType "journal-article" @default.
• W2169711067 hasAuthorship W2169711067A5017044001 @default.
• W2169711067 hasAuthorship W2169711067A5040411204 @default.
• W2169711067 hasAuthorship W2169711067A5065245949 @default.
• W2169711067 hasAuthorship W2169711067A5078194805 @default.
• W2169711067 hasAuthorship W2169711067A5085356549 @default.
• W2169711067 hasBestOaLocation W21697110671 @default.
• W2169711067 hasConcept C1122143 @default.
• W2169711067 hasConcept C122862929 @default.
• W2169711067 hasConcept C128240485 @default.
• W2169711067 hasConcept C13373296 @default.
• W2169711067 hasConcept C134018914 @default.
• W2169711067 hasConcept C136449434 @default.
• W2169711067 hasConcept C170493617 @default.
• W2169711067 hasConcept C203014093 @default.
• W2169711067 hasConcept C2776914184 @default.
• W2169711067 hasConcept C2778690821 @default.
• W2169711067 hasConcept C2779726688 @default.
• W2169711067 hasConcept C28859421 @default.
• W2169711067 hasConcept C49039625 @default.
• W2169711067 hasConcept C49802076 @default.
• W2169711067 hasConcept C55493867 @default.
• W2169711067 hasConcept C74172505 @default.
• W2169711067 hasConcept C7876069 @default.
• W2169711067 hasConcept C86803240 @default.
• W2169711067 hasConcept C8891405 @default.
• W2169711067 hasConcept C95444343 @default.
• W2169711067 hasConceptScore W2169711067C1122143 @default.
• W2169711067 hasConceptScore W2169711067C122862929 @default.
• W2169711067 hasConceptScore W2169711067C128240485 @default.
• W2169711067 hasConceptScore W2169711067C13373296 @default.
• W2169711067 hasConceptScore W2169711067C134018914 @default.
• W2169711067 hasConceptScore W2169711067C136449434 @default.
• W2169711067 hasConceptScore W2169711067C170493617 @default.

• next