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• W2169713064 abstract "Protein phosphorylation is an important regulatory mechanism involved in signal transduction and cancers. In comparison to the extensive tyrosine-kinase oncogenesis research, there are only relatively few studies of protein tyrosine-phosphatase expression in cancers. The expression profile for tyrosine-phosphatases was investigated in gastric cancers using RT-PCR and molecular cloning. The present study showed a general PTP expression profile in gastric cancer tissues, with the identification of 22 distinct tyrosine-phosphatases. Following the examination of five PTPs (PTPRA, PTPRB, PTPRD, PTPRG and PTPRZ) using immunohistochemistry, strong association was observed between PTPRA/PTPRZ expression and gastric cancer progression including lymphovascular invasion and liver/peritoneal dissemination." @default.
• W2169713064 created "2016-06-24" @default.
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• W2169713064 date "2006-10-01" @default.
• W2169713064 modified "2023-10-18" @default.
• W2169713064 title "Protein tyrosine-phosphatase expression profiling in gastric cancer tissues" @default.
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• W2169713064 doi "https://doi.org/10.1016/j.canlet.2005.10.046" @default.
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