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• W2169715187 abstract "ABSTRACT We previously reported that the cellular protein ZEB1 can repress expression of the Epstein-Barr virus (EBV) BZLF1 gene in transient transfection assays by directly binding its promoter, Zp. We also reported that EBV containing a 2-bp substitution mutation in the ZEB-binding ZV element of Zp spontaneously reactivated out of latency into lytic replication at a higher frequency than did wild-type EBV. Here, using small interfering RNA (siRNA) and short hairpin RNA (shRNA) technologies, we definitively show that ZEB1 is, indeed, a key player in maintaining EBV latency in some epithelial and B-lymphocytic cell lines. However, in other EBV-positive epithelial and B-cell lines, another zinc finger E-box-binding protein, ZEB2/SIP1, is the key player. Both ZEB1 and ZEB2 can bind Zp via the ZV element. In EBV-positive cells containing only ZEB1, knockdown of ZEB1 led to viral reactivation out of latency, with synthesis of EBV immediate-early and early lytic gene products. However, in EBV-positive cells containing both ZEBs, ZEB2, not ZEB1, was the primary ZEB family member bound to Zp. Knockdown of ZEB2, but not ZEB1, led to EBV lytic reactivation. Thus, we conclude that either ZEB1 or ZEB2 can play a central role in the maintenance of EBV latency, doing so in a cell-type-dependent manner." @default.
• W2169715187 created "2016-06-24" @default.
• W2169715187 creator A5004807867 @default.
• W2169715187 creator A5006133283 @default.
• W2169715187 creator A5022719891 @default.
• W2169715187 creator A5059906905 @default.
• W2169715187 date "2010-06-15" @default.
• W2169715187 modified "2023-09-27" @default.
• W2169715187 title "Either ZEB1 or ZEB2/SIP1 Can Play a Central Role in Regulating the Epstein-Barr Virus Latent-Lytic Switch in a Cell-Type-Specific Manner" @default.
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• W2169715187 cites W1525526263 @default.
• W2169715187 cites W1779430599 @default.
• W2169715187 cites W1955814132 @default.
• W2169715187 cites W1963973972 @default.
• W2169715187 cites W1965027943 @default.
• W2169715187 cites W1969873417 @default.
• W2169715187 cites W1976324983 @default.
• W2169715187 cites W1981785841 @default.
• W2169715187 cites W1983991097 @default.
• W2169715187 cites W1984430627 @default.
• W2169715187 cites W1985124754 @default.
• W2169715187 cites W1986326295 @default.
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• W2169715187 cites W1986806711 @default.
• W2169715187 cites W1988472957 @default.
• W2169715187 cites W1998742383 @default.
• W2169715187 cites W1999351680 @default.
• W2169715187 cites W2001514368 @default.
• W2169715187 cites W2003845256 @default.
• W2169715187 cites W2009993892 @default.
• W2169715187 cites W2011472703 @default.
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• W2169715187 cites W2019728262 @default.
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• W2169715187 cites W2025647419 @default.
• W2169715187 cites W2026629000 @default.
• W2169715187 cites W2026795477 @default.
• W2169715187 cites W2030194693 @default.
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• W2169715187 cites W2050935214 @default.
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• W2169715187 cites W2084278918 @default.
• W2169715187 cites W2085161568 @default.
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• W2169715187 doi "https://doi.org/10.1128/jvi.02706-09" @default.
• W2169715187 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2876653" @default.
• W2169715187 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20375168" @default.
• W2169715187 hasPublicationYear "2010" @default.
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