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• W2169719983 abstract "ADP plays a key role in hemostasis and thrombosis. Despite its early identification in 1961 as the first known aggregating agent, the molecular basis of ADP-induced platelet activation is only beginning to be understood. The present review proposes a model of 3 purinergic receptors contributing separately to the complex process of ADP-induced platelet aggregation: the P2X(1) ionotropic receptor, responsible for rapid influx of ionized calcium into the cytosol; the P2Y(1) metabotropic receptor, responsible for mobilization of ionized calcium from internal stores, which initiates aggregation; and an as-yet-unidentified P2Y receptor coupled to G(alphai2), which is essential for the full aggregation response to ADP. It is probable that this as-yet-unidentified receptor is the molecular target of the ADP-selective antiaggregating drugs ticlopidine and clopidogrel. In addition, it is probably defective in patients with a bleeding diathesis that is characterized by selective impairment of platelet responses to ADP." @default.
• W2169719983 created "2016-06-24" @default.
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• W2169719983 date "1999-10-01" @default.
• W2169719983 modified "2023-10-16" @default.
• W2169719983 title "ADP Receptors and Clinical Bleeding Disorders" @default.
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• W2169719983 doi "https://doi.org/10.1161/01.atv.19.10.2281" @default.
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