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- W2169725545 abstract "Chagas disease (ChD) remains a major public health problem in Latin America and it is an emerging disease in non-endemic countries [ [1] Schmunis G.A. Yadon Z.E. Chagas disease: a Latin American health problem becoming a world health problem. Acta Trop. Jul-Aug 2010; 115: 14-21 Crossref PubMed Scopus (596) Google Scholar ]. ChD is an important cause of ischemic cerebrovascular events (ICE), which result in a substantial long-term disability [ 2 Nunes M.C. Barbosa M.M. Ribeiro A.L. Barbosa F.B. Rocha M.O. Ischemic cerebrovascular events in patients with Chagas cardiomyopathy: a prospective follow-up study. J Neurol Sci. Mar 15 2009; 278: 96-101 Abstract Full Text Full Text PDF PubMed Scopus (43) Google Scholar , 3 Paixao L.C. Ribeiro A.L. Valacio R.A. Teixeira A.L. Chagas disease: independent risk factor for stroke. Stroke. Dec 2009; 40: 3691-3694 Crossref PubMed Scopus (45) Google Scholar , 4 Carod-Artal F.J. Vargas A.P. Horan T.A. Nunes L.G. Chagasic cardiomyopathy is independently associated with ischemic stroke in Chagas disease. Stroke. May 2005; 36: 965-970 Crossref PubMed Scopus (118) Google Scholar , 5 Souza A.C. Rocha M.O. Teixeira A.L. Dias Junior J.O. Sousa L.A. Nunes M.C. Depressive symptoms and disability in chagasic stroke patients: impact on functionality and quality of life. J Neurol Sci. Jan 15 2013; 324: 34-37 Abstract Full Text Full Text PDF PubMed Scopus (14) Google Scholar ] and risk of death [ [6] Lima-Costa M.F. Matos D.L. Ribeiro A.L. Chagas disease predicts 10-year stroke mortality in community-dwelling elderly: the Bambui cohort study of aging. Stroke. Nov 2010; 41: 2477-2482 Crossref PubMed Scopus (50) Google Scholar ]. Cardioembolic source for thrombi is considered to be the main pathophysiological mechanism, related to apical aneurysms, heart failure and arrhythmias [ [2] Nunes M.C. Barbosa M.M. Ribeiro A.L. Barbosa F.B. Rocha M.O. Ischemic cerebrovascular events in patients with Chagas cardiomyopathy: a prospective follow-up study. J Neurol Sci. Mar 15 2009; 278: 96-101 Abstract Full Text Full Text PDF PubMed Scopus (43) Google Scholar ]. However, ChD also compromises microvasculature function, which may contribute to the risk of ischemic events [ [7] Hassan G.S. Mukherjee S. Nagajyothi F. et al. Trypanosoma cruzi infection induces proliferation of vascular smooth muscle cells. Infect Immun. Jan 2006; 74: 152-159 Crossref PubMed Scopus (32) Google Scholar ]. The vascular dysfunction in Chagas disease is multifactorial, involving infection-associated microvascular spasm, reduction in blood flow, increased platelet aggregation, and increased myocardial inflammation and fibrosis [ [7] Hassan G.S. Mukherjee S. Nagajyothi F. et al. Trypanosoma cruzi infection induces proliferation of vascular smooth muscle cells. Infect Immun. Jan 2006; 74: 152-159 Crossref PubMed Scopus (32) Google Scholar ]. Although vascular inflammatory injuries have been associated with Trypanosoma cruzi infection in animal experimental studies [ [8] Tanowitz H.B. Kaul D.K. Chen B. et al. Compromised microcirculation in acute murine Trypanosoma cruzi infection. J Parasitol. Feb 1996; 82: 124-130 Crossref PubMed Scopus (70) Google Scholar ], the association between the vasculopathy in Chagas disease and ischemic events has not been studied in a clinical setting." @default.
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- W2169725545 date "2014-10-01" @default.
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- W2169725545 title "Assessment of the source of ischemic cerebrovascular events in patients with Chagas disease" @default.
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- W2169725545 doi "https://doi.org/10.1016/j.ijcard.2014.07.266" @default.
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