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• W2169726998 abstract "Moraxella catarrhalis causes respiratory tract infections in children and in adults with chronic obstructive pulmonary disease. It is often isolated as a copathogen with Haemophilus influenzae. The underlying mechanism for this cohabitation is unclear. Here, in clinical specimens from a patient with M. catarrhalis infection, we document that outer membrane vesicles (OMVs) carrying ubiquitous surface protein (Usp) A1 and UspA2 (hereafter, UspA1/A2) were secreted. Further analyses revealed that OMVs isolated in vitro also contained UspA1/A2, which mediate interactions with, among other proteins, the third component of the complement system (C3). OMVs from M. catarrhalis wild-type clinical strains bound to C3 and counteracted the complement cascade to a larger extent than did OMVs without UspA1/A2. In contrast, UspA1/A2-deficient OMVs were significantly weaker inhibitors of complement-dependent killing of H. influenzae. Thus, our results suggest that a novel strategy exists in which pathogens collaborate to conquer innate immunity and that the M. catarrhalis vaccine candidates UspA1/A2 play a major role in this interaction." @default.
• W2169726998 created "2016-06-24" @default.
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• W2169726998 date "2007-06-01" @default.
• W2169726998 modified "2023-09-28" @default.
• W2169726998 title "<i>Haemophilus influenzae</i>Survival during Complement‐Mediated Attacks Is Promoted by<i>Moraxella catarrhalis</i>Outer Membrane Vesicles" @default.
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• W2169726998 doi "https://doi.org/10.1086/517611" @default.
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