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• W2169733377 abstract "Medical therapy of mild and moderate ulcerative colitis (UC) of any extent is evidence-based and standardized by national and international guidelines. However, patients with steroid-refractory UC still represent a challenge.A literature search using PubMed (search terms: ulcerative colitis, therapy, new, 1-2008-2015) resulted in 821 publications. For the current article, 88 citations were extracted including 36 randomized controlled studies, 18 reviews, and 8 meta-analyses.In steroid-refractory UC, early intensive therapy using anti-tumor necrosis factor (TNF) antibodies or the calcineurin inhibitors cyclosporine and tacrolimus is indicated in any case to prevent progression to a toxic megacolon and/or to avoid proctocolectomy. In patients with chronic disease activity, treatment with anti-TNF antibodies has a higher level of evidence than azathioprine therapy and should therefore be preferred. However, there is a subgroup of UC patients who may achieve prolonged steroid-free remission on azathioprine monotherapy. The importance of vedolizumab, a newly registered inhibiting antibody against integrin, has not yet been fully clarified since direct comparison studies are lacking, in particular in relation to anti-TNF antibodies.There is a great need for additional innovative therapies, especially in cases of primary non-response or secondary loss of response to anti-TNF antibodies. New small molecules (Janus kinase inhibitors) are promising with an acceptable safety profile and efficacy in UC. Further, strategies that target the intestinal microbiome are currently considered for patients with active or relapsing UC, and may in the future open up new therapeutic options." @default.
• W2169733377 created "2016-06-24" @default.
• W2169733377 creator A5024960174 @default.
• W2169733377 creator A5031708633 @default.
• W2169733377 creator A5061864013 @default.
• W2169733377 creator A5078081528 @default.
• W2169733377 date "2015-01-01" @default.
• W2169733377 modified "2023-09-26" @default.
• W2169733377 title "Medical Therapy of Active Ulcerative Colitis" @default.
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• W2169733377 doi "https://doi.org/10.1159/000436959" @default.
• W2169733377 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4608602" @default.
• W2169733377 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26557831" @default.

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