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- W2169737900 abstract "Acute agranulocytosis is a rare, potentially life-threatening condition, which is attributable to drugs in > 70% of cases. Agranulocytosis is characterised by a peripheral neutrophil count < 0.5 × 109/l. It often manifests with a severe sore throat, but isolated fever, pneumonia or septicaemia are not uncommon. Agranulocytosis may be caused by many drugs. High-risk drugs include antithyroid drugs, clozapine, ticlopidine, sulfasalazine, dipyrone, trimethoprim/sulfamethoxazole, carbamazepine and probably rituximab. Suspect drugs should be stopped immediately. In febrile patients, blood cultures and, where indicated, site-specific cultures should be obtained and treatment with empirical broad spectrum antibiotics started. Haematopoietic growth factors should be considered in patients with poor prognostic factors (e.g., a neutrophil count < 0.1 × 109/l), severe clinical infection or severe underlying disease or comorbidity. Case fatality has decreased to ~ 5% in recent years, probably owing to improved intensive care treatment and increased alertness of physicians to this severe adverse reaction." @default.
- W2169737900 created "2016-06-24" @default.
- W2169737900 creator A5043350936 @default.
- W2169737900 date "2007-05-01" @default.
- W2169737900 modified "2023-10-12" @default.
- W2169737900 title "Non-chemotherapy drug-induced agranulocytosis" @default.
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- W2169737900 doi "https://doi.org/10.1517/14740338.6.3.323" @default.
- W2169737900 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17480181" @default.
- W2169737900 hasPublicationYear "2007" @default.
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