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- W2169748018 abstract "Substituted 1,4-benzoxazines bearing an amino side chain at the 2-position were prepared and were found to have a moderate activity on intracellular calcium. Of the compounds studied it was found that those which possess a homoveratrylamino moiety exhibited superior potency. The chain length and the nature of the amine (4-fluorophenylpiperazine, 4-fluorobenzhydryloxyethylamine, N-substituted homoveratrylamine) is discussed. The 4-benzyl-3, 4-dihydro-2-[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]propyl]-2H-1, 4-benzoxazine (3c) is the most potent derivative of the series with a ratio of IC50 values against PE (phenylephrine) and K+ of 2.1. Under these test conditions a ratio near 1 indicates potential intracellular calcium activity while a ratio greater than 100 an action on extracellular calcium influx." @default.
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- W2169748018 date "1998-07-17" @default.
- W2169748018 modified "2023-10-11" @default.
- W2169748018 title "New Substituted 1,4-Benzoxazine Derivatives with Potential Intracellular Calcium Activity" @default.
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- W2169748018 doi "https://doi.org/10.1021/jm970795t" @default.
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