Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169749991> ?p ?o ?g. }
- W2169749991 endingPage "3033" @default.
- W2169749991 startingPage "3019" @default.
- W2169749991 abstract "Microglial cells are activated during excitotoxin-induced neurodegeneration. However, the in vivo role of microglia activation in neurodegeneration has not yet been fully elucidated. To this end, we used Ikkβ conditional knockout mice (LysM-Cre/IkkβF/F) in which the Ikkβ gene is specifically deleted in cells of myeloid lineage, including microglia, in the CNS. This deletion reduced IκB kinase (IKK) activity in cultured primary microglia by up to 40% compared with wild-type (IkkβF/F), and lipopolysaccharide-induced proinflammatory gene expression was also compromised. Kainic acid (KA)-induced hippocampal neuronal cell death was reduced by 30% in LysM-Cre/IkkβF/F mice compared with wild-type mice. Reduced neuronal cell death was accompanied by decreased KA-induced glial cell activation and subsequent expression of proinflammatory genes such as tumour necrosis factor (TNF)-α and interleukin (IL)-1β. Similarly, neurons in organotypic hippocampal slice cultures (OHSCs) from LysM-Cre/IkkβF/F mouse brain were less susceptible to KA-induced excitotoxicity compared with wild-type OHSCs, due in part to decreased TNF-α and IL-1β expression. Based on these data, we concluded that IKK/nuclear factor-κB dependent microglia activation contributes to KA-induced hippocampal neuronal cell death in vivo through induction of inflammatory mediators." @default.
- W2169749991 created "2016-06-24" @default.
- W2169749991 creator A5007205584 @default.
- W2169749991 creator A5008815701 @default.
- W2169749991 creator A5038965552 @default.
- W2169749991 creator A5049872669 @default.
- W2169749991 creator A5051275961 @default.
- W2169749991 creator A5056315342 @default.
- W2169749991 creator A5063401549 @default.
- W2169749991 creator A5066834742 @default.
- W2169749991 creator A5068968670 @default.
- W2169749991 creator A5077093336 @default.
- W2169749991 creator A5081221518 @default.
- W2169749991 creator A5083378514 @default.
- W2169749991 creator A5088283936 @default.
- W2169749991 date "2008-09-26" @default.
- W2169749991 modified "2023-10-12" @default.
- W2169749991 title "Role of microglial IKKβ in kainic acid-induced hippocampal neuronal cell death" @default.
- W2169749991 cites W111663151 @default.
- W2169749991 cites W1486878670 @default.
- W2169749991 cites W1593600686 @default.
- W2169749991 cites W1595293335 @default.
- W2169749991 cites W1600123087 @default.
- W2169749991 cites W1966449387 @default.
- W2169749991 cites W1967916919 @default.
- W2169749991 cites W1976467696 @default.
- W2169749991 cites W1981126619 @default.
- W2169749991 cites W1984726237 @default.
- W2169749991 cites W1987863510 @default.
- W2169749991 cites W1993497653 @default.
- W2169749991 cites W1997577480 @default.
- W2169749991 cites W2001751662 @default.
- W2169749991 cites W2004349171 @default.
- W2169749991 cites W2004930517 @default.
- W2169749991 cites W2005648670 @default.
- W2169749991 cites W2006376420 @default.
- W2169749991 cites W2013662783 @default.
- W2169749991 cites W2017850724 @default.
- W2169749991 cites W2024476573 @default.
- W2169749991 cites W2033042047 @default.
- W2169749991 cites W2033104900 @default.
- W2169749991 cites W2033242795 @default.
- W2169749991 cites W2036364776 @default.
- W2169749991 cites W2046096265 @default.
- W2169749991 cites W2047583594 @default.
- W2169749991 cites W2047716965 @default.
- W2169749991 cites W2054113452 @default.
- W2169749991 cites W2058530689 @default.
- W2169749991 cites W2060603089 @default.
- W2169749991 cites W2061163173 @default.
- W2169749991 cites W2068210940 @default.
- W2169749991 cites W2074411774 @default.
- W2169749991 cites W2075964433 @default.
- W2169749991 cites W2079080506 @default.
- W2169749991 cites W2084121027 @default.
- W2169749991 cites W2084243555 @default.
- W2169749991 cites W2088730075 @default.
- W2169749991 cites W2092272732 @default.
- W2169749991 cites W2092749732 @default.
- W2169749991 cites W2097465856 @default.
- W2169749991 cites W2107277218 @default.
- W2169749991 cites W2113617025 @default.
- W2169749991 cites W2115064726 @default.
- W2169749991 cites W2115451328 @default.
- W2169749991 cites W2117036786 @default.
- W2169749991 cites W2124076790 @default.
- W2169749991 cites W2124667416 @default.
- W2169749991 cites W2129242841 @default.
- W2169749991 cites W2162693284 @default.
- W2169749991 cites W2170785039 @default.
- W2169749991 cites W2209229458 @default.
- W2169749991 cites W2333658997 @default.
- W2169749991 cites W4300196626 @default.
- W2169749991 cites W4322703208 @default.
- W2169749991 doi "https://doi.org/10.1093/brain/awn230" @default.
- W2169749991 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2577806" @default.
- W2169749991 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18819987" @default.
- W2169749991 hasPublicationYear "2008" @default.
- W2169749991 type Work @default.
- W2169749991 sameAs 2169749991 @default.
- W2169749991 citedByCount "140" @default.
- W2169749991 countsByYear W21697499912012 @default.
- W2169749991 countsByYear W21697499912013 @default.
- W2169749991 countsByYear W21697499912014 @default.
- W2169749991 countsByYear W21697499912015 @default.
- W2169749991 countsByYear W21697499912016 @default.
- W2169749991 countsByYear W21697499912017 @default.
- W2169749991 countsByYear W21697499912018 @default.
- W2169749991 countsByYear W21697499912019 @default.
- W2169749991 countsByYear W21697499912020 @default.
- W2169749991 countsByYear W21697499912021 @default.
- W2169749991 countsByYear W21697499912022 @default.
- W2169749991 countsByYear W21697499912023 @default.
- W2169749991 crossrefType "journal-article" @default.
- W2169749991 hasAuthorship W2169749991A5007205584 @default.
- W2169749991 hasAuthorship W2169749991A5008815701 @default.
- W2169749991 hasAuthorship W2169749991A5038965552 @default.
- W2169749991 hasAuthorship W2169749991A5049872669 @default.