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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169757199> ?p ?o ?g. }

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• W2169757199 abstract "ABSTRACT Hepatitis C virus (HCV) F protein is a newly discovered HCV gene product that is expressed by translational ribosomal frameshift. Little is known about the biological properties of this protein. By performing pulse-chase labeling experiments, we demonstrate here that the F protein is a labile protein with a half-life of <10 min in Huh7 hepatoma cells and in vitro. The half-life of the F protein could be substantially increased by proteasome inhibitors, suggesting that the rapid degradation of the F protein is mediated by the proteasome pathway. Further immunofluorescence staining and subcellular fractionation experiments indicate that the F protein is primarily associated with the endoplasmic reticulum. This subcellular localization is similar to those of HCV core and NS5A proteins, raising the possibility that the F protein may participate in HCV morphogenesis or replication." @default.
• W2169757199 created "2016-06-24" @default.
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• W2169757199 date "2003-01-15" @default.
• W2169757199 modified "2023-09-24" @default.
• W2169757199 title "Hepatitis C Virus F Protein Is a Short-Lived Protein Associated with the Endoplasmic Reticulum" @default.
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• W2169757199 doi "https://doi.org/10.1128/jvi.77.2.1578-1583.2003" @default.
• W2169757199 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/140853" @default.
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