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• W2169758355 abstract "ABSTRACT In Escherichia coli , the expression of sodB , which encodes iron superoxide dismutase, has been suggested to be activated by Fur, the iron-responsive global regulator initially characterized as a transcriptional repressor. We investigated sodB regulation by functional analysis of the sodB promoter using sodB-lac fusions with various truncated and mutated promoters. Several cis - and trans -acting elements involved in sodB regulation have been identified. The β-galactosidase activity of sodB-lacZ reporter fusions and RNA analysis showed sevenfold iron-dependent, Fur-mediated activation of expression. A region just downstream from −10, including a large palindromic sequence encompassing the +1 position followed by a 14-bp AT-rich motif, is the site of Fur positive regulation, and the integrity of both sequences was required for full Fur-mediated activation. The life span of sodB mRNA was three times longer in a fur + strain, indicating that Fur-mediated activation proceeds, at least in part, at the posttranscriptional level. The H-NS and IHF histone-like factors also affected sodB expression. IHF slightly repressed sodB expression independently of Fur regulation. In contrast, H-NS negative regulation operated only in the absence of Fur. Remarkably, p sodB behaved like a “pure extended -10” promoter. Deletion of the −35 region did not affect expression, whereas expression was totally abolished by a TG-to-CC mutation in the extended −10 sequence TGcTACCCT." @default.
• W2169758355 created "2016-06-24" @default.
• W2169758355 creator A5026394131 @default.
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• W2169758355 date "2000-07-01" @default.
• W2169758355 modified "2023-10-13" @default.
• W2169758355 title "Fur Positive Regulation of Iron Superoxide Dismutase in <i>Escherichia coli</i> : Functional Analysis of the <i>sodB</i> Promoter" @default.
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• W2169758355 doi "https://doi.org/10.1128/jb.182.13.3802-3808.2000" @default.
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