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- W2169758483 abstract "The interleukin (IL)-4 −589-C/T polymorphism has been reported to protect against human immunodeficiency virus type 1 (HIV-1)-related disease progression in white adults. In the present study, the effect of the IL-4 −589 polymorphism on HIV-1-related disease progression was evaluated in a seroprevalent cohort of 1043 children. The IL-4 −589-T allele was more prevalent in Hispanic and in black, non- Hispanic children, compared with white, non-Hispanic children. We found that the IL-4 −589-C/T polymorphism does not affect the risk of HIV-1-related disease progression or central nervous system impairment in children, and this did not differ by race/ethnicity. Our findings suggest that the IL-4 −589-C/T polymorphism is not an important determinant of HIV-1 disease progression in children." @default.
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- W2169758483 date "2004-02-15" @default.
- W2169758483 modified "2023-10-11" @default.
- W2169758483 title "Lack of Protective Effects of Interleukin‐4 −589‐C/T Polymorphism against HIV‐1–Related Disease Progression and Central Nervous System Impairment, in Children" @default.
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- W2169758483 doi "https://doi.org/10.1086/381460" @default.
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