Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169760336> ?p ?o ?g. }
- W2169760336 endingPage "1668" @default.
- W2169760336 startingPage "1656" @default.
- W2169760336 abstract "The paraventricular thalamic nucleus (PVT) receives one of the most dense innervations by hypothalamic hypocretin/orexin (Hcrt) neurons, which play important roles in sleep-wakefulness, attention, and autonomic function. The PVT projects to several loci, including the medial prefrontal cortex (mPFC), a cortical region involved in associative function and attention. To study the effect of Hcrt on excitatory PVT neurons that project to the mPFC, we used a new line of transgenic mice expressing green fluorescent protein (GFP) under the control of the vesicular glutamate-transporter-2 promoter. These neurons were retrogradely labeled with cholera toxin subunit B that had been microinjected into the mPFC. Membrane characteristics and responses to hypocretin-1 and -2 (Hcrt-1 and -2) were studied using whole cell recording ( n > 300). PVT neurons showed distinct membrane properties including inward rectification, H-type potassium currents, low threshold spikes, and spike frequency adaptation. Cortically projecting neurons were depolarized and excited by Hcrt-2. Hcrt-2 actions were stronger than those of Hcrt-1, and the action persisted in TTX and in low calcium/high magnesium artificial cerebrospinal fluid, consistent with direct actions mediated by Hcrt receptor-2. Two mechanisms of Hcrt excitation were found: an increase in input resistance caused by closure of potassium channels and activation of nonselective cation channels. The robust excitation evoked by Hcrt-2 on cortically projecting glutamate PVT neurons could generate substantial excitation in multiple layers of the mPFC, adding to the more selective direct excitatory actions of Hcrt in the mPFC and potentially increasing cortical arousal and attention to limbic or visceral states." @default.
- W2169760336 created "2016-06-24" @default.
- W2169760336 creator A5004172478 @default.
- W2169760336 creator A5061112877 @default.
- W2169760336 creator A5077246875 @default.
- W2169760336 date "2006-03-01" @default.
- W2169760336 modified "2023-10-11" @default.
- W2169760336 title "Prefrontal Cortex–Projecting Glutamatergic Thalamic Paraventricular Nucleus-Excited by Hypocretin: A Feedforward Circuit That May Enhance Cognitive Arousal" @default.
- W2169760336 cites W1488974332 @default.
- W2169760336 cites W1608422293 @default.
- W2169760336 cites W1627229807 @default.
- W2169760336 cites W1825581609 @default.
- W2169760336 cites W1847742796 @default.
- W2169760336 cites W1959892192 @default.
- W2169760336 cites W1964399514 @default.
- W2169760336 cites W1970821249 @default.
- W2169760336 cites W1972289026 @default.
- W2169760336 cites W1977412641 @default.
- W2169760336 cites W1980656761 @default.
- W2169760336 cites W1981775108 @default.
- W2169760336 cites W1994949307 @default.
- W2169760336 cites W1998722012 @default.
- W2169760336 cites W2006107271 @default.
- W2169760336 cites W2008360236 @default.
- W2169760336 cites W2011661288 @default.
- W2169760336 cites W2012483271 @default.
- W2169760336 cites W2013655437 @default.
- W2169760336 cites W2014731714 @default.
- W2169760336 cites W2016656256 @default.
- W2169760336 cites W2017200167 @default.
- W2169760336 cites W2017934537 @default.
- W2169760336 cites W2019910740 @default.
- W2169760336 cites W2020694953 @default.
- W2169760336 cites W2027740042 @default.
- W2169760336 cites W2027749726 @default.
- W2169760336 cites W2028121897 @default.
- W2169760336 cites W2028258541 @default.
- W2169760336 cites W2028474222 @default.
- W2169760336 cites W2028632223 @default.
- W2169760336 cites W2031462960 @default.
- W2169760336 cites W2031830498 @default.
- W2169760336 cites W2040700968 @default.
- W2169760336 cites W2041731336 @default.
- W2169760336 cites W2042388304 @default.
- W2169760336 cites W2049088920 @default.
- W2169760336 cites W2049851008 @default.
- W2169760336 cites W2050123488 @default.
- W2169760336 cites W2050980301 @default.
- W2169760336 cites W2058159881 @default.
- W2169760336 cites W2072154498 @default.
- W2169760336 cites W2072809118 @default.
- W2169760336 cites W2077425962 @default.
- W2169760336 cites W2082138888 @default.
- W2169760336 cites W2083155159 @default.
- W2169760336 cites W2085070592 @default.
- W2169760336 cites W2086714775 @default.
- W2169760336 cites W2088688806 @default.
- W2169760336 cites W2096879872 @default.
- W2169760336 cites W2097350866 @default.
- W2169760336 cites W2097728402 @default.
- W2169760336 cites W2099808541 @default.
- W2169760336 cites W2100149588 @default.
- W2169760336 cites W2102737392 @default.
- W2169760336 cites W2115902692 @default.
- W2169760336 cites W2119279851 @default.
- W2169760336 cites W2121147520 @default.
- W2169760336 cites W2122196568 @default.
- W2169760336 cites W2124865173 @default.
- W2169760336 cites W2134333835 @default.
- W2169760336 cites W2136690680 @default.
- W2169760336 cites W2136715772 @default.
- W2169760336 cites W2137303544 @default.
- W2169760336 cites W2137422526 @default.
- W2169760336 cites W2143557510 @default.
- W2169760336 cites W2150497419 @default.
- W2169760336 cites W2152211310 @default.
- W2169760336 cites W2158046822 @default.
- W2169760336 cites W2169378022 @default.
- W2169760336 cites W2171263984 @default.
- W2169760336 cites W2409034938 @default.
- W2169760336 cites W4213213297 @default.
- W2169760336 cites W4239900521 @default.
- W2169760336 doi "https://doi.org/10.1152/jn.00927.2005" @default.
- W2169760336 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16492946" @default.
- W2169760336 hasPublicationYear "2006" @default.
- W2169760336 type Work @default.
- W2169760336 sameAs 2169760336 @default.
- W2169760336 citedByCount "134" @default.
- W2169760336 countsByYear W21697603362012 @default.
- W2169760336 countsByYear W21697603362013 @default.
- W2169760336 countsByYear W21697603362014 @default.
- W2169760336 countsByYear W21697603362015 @default.
- W2169760336 countsByYear W21697603362016 @default.
- W2169760336 countsByYear W21697603362017 @default.
- W2169760336 countsByYear W21697603362018 @default.
- W2169760336 countsByYear W21697603362019 @default.
- W2169760336 countsByYear W21697603362020 @default.
- W2169760336 countsByYear W21697603362021 @default.