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• W2169767314 abstract "OZET Animal Models For Interstitial Cystitis/Painful Bladder Syndrome The International Continence Society has defined IC/PBS as “the complaint of suprapubic pain related to bladder filling, accompanied by other symptoms such as increased daytime and night-time frequency, in the absence of proven urinary infection or other obvious pathology” (1). IC is a chronic inflammation of the urinary bladder in the absence of verified infection (2, 3), and presents with the symptoms of frequent and urgent urination along with pain or irritation in the bladder and lower urinary tract (LUT), necessitating the addition of the new terminology painful bladder syndrome (PBS) (3-5). Complete diagnostic criteria for epidemiological studies of IC/PBS have not been established. Earlier diagnostic criteria proposed by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDKK) included a cystoscopic finding of glomerulations upon bladder distension or Hunner’s ulcer, in addition to bladder pain or urinary urgency, along with several criteria to exclude other diseases (6). However, 10% to 34% of patients with urinary urgency due to bladder pain do not exhibit glomerulations upon bladder distension and only 10% of patients diagnosed with IC present with Hunner’s ulcer (7-10). Depending on the diagnostic criteria used, the prevalence of IC/PBS has been estimated as between 0.03% to 2.0% of adults (11-13). The prevalence of IC/PBS among women is estimated to be 2 to 5 times higher than in men (3, 13). The recent Rand Epidemiology study of IC/PBS in women in the United States identified the prevalence of IC/ PBS as 6.5% and 2.7% based on high sensitivity and high specificity diagnostic criteria, respectively, which translates to 3.3 to 7.9 million women suffering from IC/PBS symptoms (14). According to the NIDDK diagnostic criteria, IC/PBS occurs 17 times more frequently in relatives of IC/PBS patients than in the general population in the United States (15). The medical costs have been estimated at more than $100 million per year in the United States (16)." @default.
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• W2169767314 date "2013-09-12" @default.
• W2169767314 modified "2023-09-27" @default.
• W2169767314 title "Animal Models for Interstitial Cystitis/Painful Bladder Syndrome (IC/PBS)" @default.
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• W2169767314 doi "https://doi.org/10.5152/etd.2013.41" @default.
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