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- W2169771432 abstract "Rejection and infection are relevant causes of mortality in heart recipients. We evaluated the kinetics of the maturation status of B lymphocytes and its relationship with acute cellular rejection and severe infection in heart recipients. We analyzed B-cell subsets using 4-color flow cytometry in a prospective follow-up study of 46 heart recipients. Lymphocyte subsets were evaluated at specific times before and up to 1 year after transplantation. Higher percentages of pretransplant class-switched memory B cells (CD19+CD27+IgM-IgD- >14%) were associated with a 74% decrease in the risk of severe infection [Cox regression relative hazard (RH) 0.26, 95% confidence interval (CI), 0.07–0.86; P = 0.027]. Patients with higher percentages of naïve B cells at day 7 after transplantation (CD19+CD27-IgM+IgD+ >58%) had a 91% decrease in the risk of developing acute cellular rejection (RH 0.09; 95% CI, 0.01–0.80; P = 0.02). Patients with infections showed a strong negative correlation between baseline serum B-cell–activating factor (BAFF) concentration and absolute counts of memory class-switched B cells (R = −0.81, P = 0.01). The evaluation of the immunophenotypic maturation status of B lymphocytes could prove to be a useful marker for identifying patients at risk of developing rejection or infection after heart transplantation." @default.
- W2169771432 created "2016-06-24" @default.
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- W2169771432 date "2013-06-10" @default.
- W2169771432 modified "2023-09-24" @default.
- W2169771432 title "Alterations of naïve and memory B-cell subsets are associated with risk of rejection and infection in heart recipients" @default.
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- W2169771432 doi "https://doi.org/10.1111/tri.12131" @default.
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