Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169771574> ?p ?o ?g. }
- W2169771574 endingPage "429" @default.
- W2169771574 startingPage "424" @default.
- W2169771574 abstract "Psychosocial stress is a risk factor for coronary heart disease (CHD), although the mechanisms are incompletely understood. We examined the cross-sectional association between the cortisol response to laboratory-induced mental stress and a marker of sub-clinical coronary atherosclerosis.Participants were 514 healthy men and women (mean age = 62.9 +/- 5.7 years), without history or objective signs of CHD, drawn from the Whitehall II epidemiological cohort. Salivary cortisol was measured in response to mental stressors, consisting of a 5 min Stroop task and a 5 min mirror tracing task. Coronary artery calcification (CAC) was measured using electron beam computed tomography. Approximately 40% of the sample responded to the stress tasks with a notable (>or=1 nmol/L) increase in cortisol. Significant CAC (Agatston score >or= 100) was recorded in 23.9% of the sample. The cortisol response group demonstrated a higher risk of significant CAC (odds ratio = 2.20, 95% CI, 1.39-3.47) after adjustments for age, gender, baseline cortisol, employment grade, and conventional risk factors, although cortisol was unrelated to the presence of detectable CAC. Among participants with detectable CAC, the cortisol response group also demonstrated higher log Agatston scores compared with non-responders (age and sex adjusted scores; 4.51 +/- 0.15 vs. 3.94 +/- 0.13, P = 0.004).In healthy, older participants without history or objective signs of CHD, heightened cortisol reactivity is associated with a greater extent of CAC. These data support the notion that heightened hypothalamic pituitary adrenal activity is a risk factor for CHD." @default.
- W2169771574 created "2016-06-24" @default.
- W2169771574 creator A5005721369 @default.
- W2169771574 creator A5027010110 @default.
- W2169771574 creator A5040846869 @default.
- W2169771574 creator A5090760820 @default.
- W2169771574 date "2009-09-10" @default.
- W2169771574 modified "2023-09-27" @default.
- W2169771574 title "Salivary cortisol responses to mental stress are associated with coronary artery calcification in healthy men and women" @default.
- W2169771574 cites W1435108658 @default.
- W2169771574 cites W1577497395 @default.
- W2169771574 cites W1601708437 @default.
- W2169771574 cites W1947690049 @default.
- W2169771574 cites W1971472848 @default.
- W2169771574 cites W1990131317 @default.
- W2169771574 cites W1990703279 @default.
- W2169771574 cites W1995064401 @default.
- W2169771574 cites W1998234914 @default.
- W2169771574 cites W1999264494 @default.
- W2169771574 cites W2011883695 @default.
- W2169771574 cites W2027066260 @default.
- W2169771574 cites W2031213401 @default.
- W2169771574 cites W2031439281 @default.
- W2169771574 cites W2045689381 @default.
- W2169771574 cites W2046179952 @default.
- W2169771574 cites W2047217999 @default.
- W2169771574 cites W2048021011 @default.
- W2169771574 cites W2049355378 @default.
- W2169771574 cites W2050891116 @default.
- W2169771574 cites W2054629340 @default.
- W2169771574 cites W2057303850 @default.
- W2169771574 cites W2061873934 @default.
- W2169771574 cites W2068458131 @default.
- W2169771574 cites W2082984203 @default.
- W2169771574 cites W2088836734 @default.
- W2169771574 cites W2091413411 @default.
- W2169771574 cites W2096978392 @default.
- W2169771574 cites W2100785280 @default.
- W2169771574 cites W2104018747 @default.
- W2169771574 cites W2104706609 @default.
- W2169771574 cites W2109018676 @default.
- W2169771574 cites W2115693713 @default.
- W2169771574 cites W2116266566 @default.
- W2169771574 cites W2123477658 @default.
- W2169771574 cites W2139191717 @default.
- W2169771574 cites W2148414912 @default.
- W2169771574 cites W2149257689 @default.
- W2169771574 cites W2154209069 @default.
- W2169771574 cites W2154910135 @default.
- W2169771574 cites W2163613769 @default.
- W2169771574 cites W2322678100 @default.
- W2169771574 doi "https://doi.org/10.1093/eurheartj/ehp386" @default.
- W2169771574 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19744954" @default.
- W2169771574 hasPublicationYear "2009" @default.
- W2169771574 type Work @default.
- W2169771574 sameAs 2169771574 @default.
- W2169771574 citedByCount "114" @default.
- W2169771574 countsByYear W21697715742012 @default.
- W2169771574 countsByYear W21697715742013 @default.
- W2169771574 countsByYear W21697715742014 @default.
- W2169771574 countsByYear W21697715742015 @default.
- W2169771574 countsByYear W21697715742016 @default.
- W2169771574 countsByYear W21697715742017 @default.
- W2169771574 countsByYear W21697715742018 @default.
- W2169771574 countsByYear W21697715742019 @default.
- W2169771574 countsByYear W21697715742020 @default.
- W2169771574 countsByYear W21697715742021 @default.
- W2169771574 countsByYear W21697715742022 @default.
- W2169771574 countsByYear W21697715742023 @default.
- W2169771574 crossrefType "journal-article" @default.
- W2169771574 hasAuthorship W2169771574A5005721369 @default.
- W2169771574 hasAuthorship W2169771574A5027010110 @default.
- W2169771574 hasAuthorship W2169771574A5040846869 @default.
- W2169771574 hasAuthorship W2169771574A5090760820 @default.
- W2169771574 hasBestOaLocation W21697715741 @default.
- W2169771574 hasConcept C107130276 @default.
- W2169771574 hasConcept C118552586 @default.
- W2169771574 hasConcept C126322002 @default.
- W2169771574 hasConcept C134018914 @default.
- W2169771574 hasConcept C139719470 @default.
- W2169771574 hasConcept C150966472 @default.
- W2169771574 hasConcept C156957248 @default.
- W2169771574 hasConcept C162324750 @default.
- W2169771574 hasConcept C164705383 @default.
- W2169771574 hasConcept C2776867660 @default.
- W2169771574 hasConcept C2778213512 @default.
- W2169771574 hasConcept C2778709874 @default.
- W2169771574 hasConcept C2780609585 @default.
- W2169771574 hasConcept C2994533308 @default.
- W2169771574 hasConcept C50440223 @default.
- W2169771574 hasConcept C558461103 @default.
- W2169771574 hasConcept C71924100 @default.
- W2169771574 hasConcept C72563966 @default.
- W2169771574 hasConceptScore W2169771574C107130276 @default.
- W2169771574 hasConceptScore W2169771574C118552586 @default.
- W2169771574 hasConceptScore W2169771574C126322002 @default.
- W2169771574 hasConceptScore W2169771574C134018914 @default.
- W2169771574 hasConceptScore W2169771574C139719470 @default.