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• W2169771822 abstract "Despite recent advances in the field, the treatment of patients with acute myeloid leukemia (AML) remains challenging and difficult. Although chemotherapeutic agents induce remissions in a large number of patients, many of them eventually relapse and die. A major goal for the development of new approaches for the treatment of AML is to enhance the antileukemic effects of standard chemotherapeutics and to design effective combinations targeting non-overlapping cellular pathways. The PI3K/Akt/mTOR signaling pathway plays a critical role in survival and growth of malignant cells and its targeting has been the focus of extensive work and research efforts over the last two decades. It now appears possible that a major limitation of the first generation of mTOR inhibitors can be overcome by a new class of catalytic inhibitors of mTOR. There is emerging evidence that such compounds target both TORC1 and TORC2 and elicit much more potent responses against early leukemic precursors in vitro. In addition, recent studies have shown that combinations of such agents with cytarabine result in enhanced antileukemic responses in vitro, raising the prospect and potential of use of these agents in combination regimens for the treatment of AML." @default.
• W2169771822 created "2016-06-24" @default.
• W2169771822 creator A5025780450 @default.
• W2169771822 creator A5051335860 @default.
• W2169771822 creator A5065775870 @default.
• W2169771822 date "2011-06-15" @default.
• W2169771822 modified "2023-09-23" @default.
• W2169771822 title "Targeting mTOR for the treatment of AML. New agents and new directions" @default.
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• W2169771822 cites W1894000260 @default.
• W2169771822 cites W1965976637 @default.
• W2169771822 cites W1966982061 @default.
• W2169771822 cites W1969167655 @default.
• W2169771822 cites W1970111367 @default.
• W2169771822 cites W1975645428 @default.
• W2169771822 cites W1981711832 @default.
• W2169771822 cites W1984621921 @default.
• W2169771822 cites W1992170852 @default.
• W2169771822 cites W1992454913 @default.
• W2169771822 cites W1994261318 @default.
• W2169771822 cites W1998639716 @default.
• W2169771822 cites W2000110198 @default.
• W2169771822 cites W2003173822 @default.
• W2169771822 cites W2007757672 @default.
• W2169771822 cites W2009886463 @default.
• W2169771822 cites W2017018900 @default.
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• W2169771822 cites W2023012828 @default.
• W2169771822 cites W2024104654 @default.
• W2169771822 cites W2036691369 @default.
• W2169771822 cites W2040331428 @default.
• W2169771822 cites W2044942890 @default.
• W2169771822 cites W2044995490 @default.
• W2169771822 cites W2047233645 @default.
• W2169771822 cites W2047392226 @default.
• W2169771822 cites W2049482339 @default.
• W2169771822 cites W2052117124 @default.
• W2169771822 cites W2054042776 @default.
• W2169771822 cites W2055729918 @default.
• W2169771822 cites W2055897952 @default.
• W2169771822 cites W2056242938 @default.
• W2169771822 cites W2065887259 @default.
• W2169771822 cites W2066880509 @default.
• W2169771822 cites W2070732456 @default.
• W2169771822 cites W2075718119 @default.
• W2169771822 cites W2078844752 @default.
• W2169771822 cites W2078936160 @default.
• W2169771822 cites W2080100938 @default.
• W2169771822 cites W2087598047 @default.
• W2169771822 cites W2087650169 @default.
• W2169771822 cites W2093604520 @default.
• W2169771822 cites W2094817491 @default.
• W2169771822 cites W2097540657 @default.
• W2169771822 cites W2097863684 @default.
• W2169771822 cites W2098912234 @default.
• W2169771822 cites W2102353246 @default.
• W2169771822 cites W2103468550 @default.
• W2169771822 cites W2104052951 @default.
• W2169771822 cites W2104461354 @default.
• W2169771822 cites W2113343850 @default.
• W2169771822 cites W2114762453 @default.
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• W2169771822 cites W2118054479 @default.
• W2169771822 cites W2120356140 @default.
• W2169771822 cites W2120943945 @default.
• W2169771822 cites W2121190158 @default.
• W2169771822 cites W2129585918 @default.
• W2169771822 cites W2131746764 @default.
• W2169771822 cites W2134719928 @default.
• W2169771822 cites W2139638366 @default.
• W2169771822 cites W2140737563 @default.
• W2169771822 cites W2143854006 @default.
• W2169771822 cites W2145260509 @default.
• W2169771822 cites W2146317534 @default.
• W2169771822 cites W2149322133 @default.
• W2169771822 cites W2151576707 @default.
• W2169771822 cites W2152289580 @default.
• W2169771822 cites W2153867442 @default.
• W2169771822 cites W2158305336 @default.
• W2169771822 cites W2158355674 @default.
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• W2169771822 cites W2159430811 @default.
• W2169771822 cites W2162920526 @default.
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• W2169771822 doi "https://doi.org/10.18632/oncotarget.290" @default.
• W2169771822 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3248202" @default.
• W2169771822 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21680954" @default.
• W2169771822 hasPublicationYear "2011" @default.
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