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• W2169771883 abstract "Fluctuations in intracellular calcium concentration ([Ca 2+ ] i ) constitute the main link in excitation-contraction coupling (E-C coupling) in airway smooth muscle cells (ASMC). It has recently been reported that ACh induces asynchronous recurring Ca 2+ waves in intact ASMC of murine bronchioles. With the use of a novel technique allowing us to simultaneously measure subcellular [Ca 2+ ] i and force generation in ASMC located within an intact tracheal muscle bundle, we examined a similar pattern of Ca 2+ signaling in the trachea. We found that application of ACh resulted in the generation of recurring intracellular Ca 2+ waves progressing along the longitudinal axis of the ribbon-shaped intact ASMC. These Ca 2+ waves were not synchronized between neighboring cells, and induction of wave-like [Ca 2+ ] i oscillations was temporally associated with development of force by the tracheal muscle bundle. By comparing the concentration dependence of force generation and the parameters characterizing the [Ca 2+ ] i oscillations, we found that the concentration-dependent increase in ACh-induced force development by the tracheal smooth muscle bundle is achieved by differential recruitment of intact ASMC to initiate Ca 2+ waves and by enhancement in the frequency of [Ca 2+ ] i oscillations and elevation of interspike [Ca 2+ ] i once the cells are recruited. Our findings demonstrate that asynchronous recurring Ca 2+ waves underlie E-C coupling in ACh-induced contraction of the intact tracheal smooth muscle bundle. Furthermore, in contrast to what was reported in enzymatically dissociated ASMC, Ca 2+ influx through the L-type voltage-gated Ca 2+ channel was not an obligatory requirement for the generation of [Ca 2+ ] i oscillations and development of force in ACh-stimulated intact ASMC." @default.
• W2169771883 created "2016-06-24" @default.
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• W2169771883 date "2003-12-01" @default.
• W2169771883 modified "2023-09-26" @default.
• W2169771883 title "Relationship between asynchronous Ca²⁺ waves and force development in intact smooth muscle bundles of the porcine trachea" @default.
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• W2169771883 doi "https://doi.org/10.1152/ajplung.00043.2003" @default.
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