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• W2169775093 abstract "Gastric and esophageal cancers were the fifth and tenth most common cancers diagnosed in Europe in 2006 and the fourth and ninth most common causes of death from cancer, respectively [1]. Surgery alone is no longer an accepted practice for any but the earliest stage disease, or for patients in whom there are contraindications to combined modality therapy, but there remains no international consensus as to the optimal peri-operative management of gastro-esophageal cancers. Large randomized controlled trials (RCTs) have attempted to define gold-standard treatment, but data comparing different treatment strategies such as peri-operative chemotherapy with adjuvant chemoradiation (CRT) for gastric cancer or neoadjuvant chemotherapy versus CRT for esophageal adenocarcinomas are still awaited. Additionally, the emergence of targeted agents such as the anti-vascular endothelial growth factor (VEGF) monoclonal antibody, bevacizumab, the epidermal growth factor receptor (EGFR) antibodies cetuximab and panitumumab and possibly tyrosine kinase inhibitors (TKIs), are likely to further change the way that operable gastro-esophageal cancers are managed." @default.
• W2169775093 created "2016-06-24" @default.
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• W2169775093 date "2008-09-01" @default.
• W2169775093 modified "2023-09-30" @default.
• W2169775093 title "Progress in the multidisciplinary treatment of gastrointestinal cancers, impact on clinical practice: peri-operative management of gastro-esophageal cancer" @default.
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• W2169775093 doi "https://doi.org/10.1093/annonc/mdn440" @default.
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