Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169782186> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2169782186 endingPage "254" @default.
- W2169782186 startingPage "254" @default.
- W2169782186 abstract "Some photochemical and photobiological properties of 4,6,8,9-tetramethyl-2H-furo[2,3-h]quinolin-2-one (HFQ) were studied in comparison with its isomer 1,4,6,8-tetramethyl-2H-furo[2,3-h]quinolin-2-one (FQ) and 8-methoxypsoralen (8-MOP). The HFQ photobinds to DNA forming furan-side monoadducts (MAHFQ) that have molecular structure very similar to those of FQ (MAFQ). Unlike MA8-MOP and MAFQ, MAHFQ no longer photoreact. The HFQ, like FQ, produces moderate amounts of singlet oxygen but no superoxide anions. The HFQ and FQ induce numbers of DNA-protein cross-links (DPC), much more plentiful than those of 8-MOP (about two and seven times, respectively) but no interstrand cross-links. The mechanism of DPC formation was studied in vivo in mammalian cells by alkaline elution and in vitro using a new test mixing histones and DNA from calf thymus. The latter is a very useful technique for the double irradiation protocol. The DNA (or histones) are separately exposed to a first UVA dose in the presence of the sensitizer; then, after its unbound molecules have been removed, histones (or DNA) are added to assemble the chromatin-like complex that is irradiated again. According to in vitro and in vivo methods, DPC appear to be formed by FQ and 8-MOP by a biphotonic process that starts with monoadduct induction in DNA, followed by their conversion into DPC. In the resulting lesions, the sensitizer molecule forms a covalent bridge between the two macromolecules (DPC at length greater than zero). Instead, HFQ induces DPC by a monophotonic process; thus, HFQ is probably not a physical part of the bridge between DNA and proteins, which may be linked together directly, like DPC at zero length induced by UVC." @default.
- W2169782186 created "2016-06-24" @default.
- W2169782186 creator A5020258774 @default.
- W2169782186 creator A5027477340 @default.
- W2169782186 creator A5035818670 @default.
- W2169782186 creator A5044015765 @default.
- W2169782186 creator A5053207148 @default.
- W2169782186 creator A5074219340 @default.
- W2169782186 creator A5085292075 @default.
- W2169782186 date "2000-01-01" @default.
- W2169782186 modified "2023-09-25" @default.
- W2169782186 title "DNA Damage Induced by 4,6,8,9-Tetramethyl-2H-furo[2,3-h]quinolin-2-one, a New Furocoumarin Analog: Photochemical Mechanisms" @default.
- W2169782186 cites W1965340064 @default.
- W2169782186 cites W1966659023 @default.
- W2169782186 cites W2013420591 @default.
- W2169782186 cites W2028928289 @default.
- W2169782186 cites W2032827416 @default.
- W2169782186 cites W2045208597 @default.
- W2169782186 cites W974598347 @default.
- W2169782186 doi "https://doi.org/10.1562/0031-8655(2000)071<0254:ddibtf>2.0.co;2" @default.
- W2169782186 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10732442" @default.
- W2169782186 hasPublicationYear "2000" @default.
- W2169782186 type Work @default.
- W2169782186 sameAs 2169782186 @default.
- W2169782186 citedByCount "3" @default.
- W2169782186 crossrefType "journal-article" @default.
- W2169782186 hasAuthorship W2169782186A5020258774 @default.
- W2169782186 hasAuthorship W2169782186A5027477340 @default.
- W2169782186 hasAuthorship W2169782186A5035818670 @default.
- W2169782186 hasAuthorship W2169782186A5044015765 @default.
- W2169782186 hasAuthorship W2169782186A5053207148 @default.
- W2169782186 hasAuthorship W2169782186A5074219340 @default.
- W2169782186 hasAuthorship W2169782186A5085292075 @default.
- W2169782186 hasConcept C12554922 @default.
- W2169782186 hasConcept C143425029 @default.
- W2169782186 hasConcept C150903083 @default.
- W2169782186 hasConcept C178790620 @default.
- W2169782186 hasConcept C180577832 @default.
- W2169782186 hasConcept C185592680 @default.
- W2169782186 hasConcept C202751555 @default.
- W2169782186 hasConcept C204389451 @default.
- W2169782186 hasConcept C20639190 @default.
- W2169782186 hasConcept C207001950 @default.
- W2169782186 hasConcept C2777516457 @default.
- W2169782186 hasConcept C2908991464 @default.
- W2169782186 hasConcept C32909587 @default.
- W2169782186 hasConcept C540031477 @default.
- W2169782186 hasConcept C552990157 @default.
- W2169782186 hasConcept C55493867 @default.
- W2169782186 hasConcept C64927066 @default.
- W2169782186 hasConcept C71240020 @default.
- W2169782186 hasConcept C75473681 @default.
- W2169782186 hasConcept C83640560 @default.
- W2169782186 hasConcept C86803240 @default.
- W2169782186 hasConceptScore W2169782186C12554922 @default.
- W2169782186 hasConceptScore W2169782186C143425029 @default.
- W2169782186 hasConceptScore W2169782186C150903083 @default.
- W2169782186 hasConceptScore W2169782186C178790620 @default.
- W2169782186 hasConceptScore W2169782186C180577832 @default.
- W2169782186 hasConceptScore W2169782186C185592680 @default.
- W2169782186 hasConceptScore W2169782186C202751555 @default.
- W2169782186 hasConceptScore W2169782186C204389451 @default.
- W2169782186 hasConceptScore W2169782186C20639190 @default.
- W2169782186 hasConceptScore W2169782186C207001950 @default.
- W2169782186 hasConceptScore W2169782186C2777516457 @default.
- W2169782186 hasConceptScore W2169782186C2908991464 @default.
- W2169782186 hasConceptScore W2169782186C32909587 @default.
- W2169782186 hasConceptScore W2169782186C540031477 @default.
- W2169782186 hasConceptScore W2169782186C552990157 @default.
- W2169782186 hasConceptScore W2169782186C55493867 @default.
- W2169782186 hasConceptScore W2169782186C64927066 @default.
- W2169782186 hasConceptScore W2169782186C71240020 @default.
- W2169782186 hasConceptScore W2169782186C75473681 @default.
- W2169782186 hasConceptScore W2169782186C83640560 @default.
- W2169782186 hasConceptScore W2169782186C86803240 @default.
- W2169782186 hasIssue "3" @default.
- W2169782186 hasLocation W21697821861 @default.
- W2169782186 hasLocation W21697821862 @default.
- W2169782186 hasOpenAccess W2169782186 @default.
- W2169782186 hasPrimaryLocation W21697821861 @default.
- W2169782186 hasRelatedWork W1971975020 @default.
- W2169782186 hasRelatedWork W1988409369 @default.
- W2169782186 hasRelatedWork W1992264433 @default.
- W2169782186 hasRelatedWork W1994318583 @default.
- W2169782186 hasRelatedWork W1996557633 @default.
- W2169782186 hasRelatedWork W2039047912 @default.
- W2169782186 hasRelatedWork W2080042161 @default.
- W2169782186 hasRelatedWork W2083040611 @default.
- W2169782186 hasRelatedWork W2327946364 @default.
- W2169782186 hasRelatedWork W2491248937 @default.
- W2169782186 hasVolume "71" @default.
- W2169782186 isParatext "false" @default.
- W2169782186 isRetracted "false" @default.
- W2169782186 magId "2169782186" @default.
- W2169782186 workType "article" @default.