Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169794847> ?p ?o ?g. }
- W2169794847 endingPage "753" @default.
- W2169794847 startingPage "743" @default.
- W2169794847 abstract "The DNA damage checkpoint kinase Rad53 is important for the survival of budding yeast under genotoxic stresses. We performed a biochemical screen to identify proteins with specific affinity for the two Forkhead associated (FHA) domains of Rad53. The N-terminal FHA1 domain was found to coordinate a complex protein interaction network, which includes nuclear proteins involved in DNA damage checkpoints and transcriptional regulation. Unexpectedly, cytosolic proteins involved in cytokinesis, including septins, were also found as FHA1 binding proteins. Consistent with this interaction, a Rad53 mutant defective in its nuclear localization was found to localize to the bud neck. Abnormal morphology was observed in cells overexpressing the FHA1 domain and in rad53Δ cells under DNA replication stress. Further, septin Shs1 appears to have an important role in the response to DNA replication stress. Collectively, the results suggest a novel function of Rad53 in the regulation of polarized cell growth in response to DNA replication stress." @default.
- W2169794847 created "2016-06-24" @default.
- W2169794847 creator A5014277891 @default.
- W2169794847 creator A5025725461 @default.
- W2169794847 creator A5031897845 @default.
- W2169794847 creator A5043368519 @default.
- W2169794847 creator A5050379587 @default.
- W2169794847 creator A5057471078 @default.
- W2169794847 creator A5060382413 @default.
- W2169794847 creator A5081915207 @default.
- W2169794847 creator A5087017498 @default.
- W2169794847 date "2006-11-27" @default.
- W2169794847 modified "2023-10-16" @default.
- W2169794847 title "An FHA domain–mediated protein interaction network of Rad53 reveals its role in polarized cell growth" @default.
- W2169794847 cites W1564916342 @default.
- W2169794847 cites W1566625041 @default.
- W2169794847 cites W1597133026 @default.
- W2169794847 cites W1752089945 @default.
- W2169794847 cites W1964491373 @default.
- W2169794847 cites W1965980401 @default.
- W2169794847 cites W1966072209 @default.
- W2169794847 cites W1967095672 @default.
- W2169794847 cites W1971040573 @default.
- W2169794847 cites W1978966221 @default.
- W2169794847 cites W1986121915 @default.
- W2169794847 cites W1986157458 @default.
- W2169794847 cites W1995479856 @default.
- W2169794847 cites W2004373779 @default.
- W2169794847 cites W2006765383 @default.
- W2169794847 cites W2008187459 @default.
- W2169794847 cites W2010255232 @default.
- W2169794847 cites W2011287943 @default.
- W2169794847 cites W2019790163 @default.
- W2169794847 cites W2021601545 @default.
- W2169794847 cites W2022893562 @default.
- W2169794847 cites W2034195376 @default.
- W2169794847 cites W2036692074 @default.
- W2169794847 cites W2037036397 @default.
- W2169794847 cites W2049353065 @default.
- W2169794847 cites W2051302495 @default.
- W2169794847 cites W2053960419 @default.
- W2169794847 cites W2055604308 @default.
- W2169794847 cites W2056140785 @default.
- W2169794847 cites W2057764157 @default.
- W2169794847 cites W2060107244 @default.
- W2169794847 cites W2061617964 @default.
- W2169794847 cites W2062426541 @default.
- W2169794847 cites W2063607742 @default.
- W2169794847 cites W2065414469 @default.
- W2169794847 cites W2069334332 @default.
- W2169794847 cites W2078957361 @default.
- W2169794847 cites W2079406109 @default.
- W2169794847 cites W2082941148 @default.
- W2169794847 cites W2084619201 @default.
- W2169794847 cites W2090601888 @default.
- W2169794847 cites W2098324291 @default.
- W2169794847 cites W2102566010 @default.
- W2169794847 cites W2104565193 @default.
- W2169794847 cites W2113439921 @default.
- W2169794847 cites W2116202869 @default.
- W2169794847 cites W2116468279 @default.
- W2169794847 cites W2116774827 @default.
- W2169794847 cites W2121503963 @default.
- W2169794847 cites W2122259228 @default.
- W2169794847 cites W2125782229 @default.
- W2169794847 cites W2125902086 @default.
- W2169794847 cites W2127390714 @default.
- W2169794847 cites W2133643647 @default.
- W2169794847 cites W2138122869 @default.
- W2169794847 cites W2139609470 @default.
- W2169794847 cites W2144365463 @default.
- W2169794847 cites W2148146668 @default.
- W2169794847 cites W2148333280 @default.
- W2169794847 cites W2148530409 @default.
- W2169794847 cites W2150261056 @default.
- W2169794847 cites W2150688223 @default.
- W2169794847 cites W2159656070 @default.
- W2169794847 cites W2165337946 @default.
- W2169794847 cites W2397944365 @default.
- W2169794847 doi "https://doi.org/10.1083/jcb.200605081" @default.
- W2169794847 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2064674" @default.
- W2169794847 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17130285" @default.
- W2169794847 hasPublicationYear "2006" @default.
- W2169794847 type Work @default.
- W2169794847 sameAs 2169794847 @default.
- W2169794847 citedByCount "85" @default.
- W2169794847 countsByYear W21697948472012 @default.
- W2169794847 countsByYear W21697948472013 @default.
- W2169794847 countsByYear W21697948472014 @default.
- W2169794847 countsByYear W21697948472015 @default.
- W2169794847 countsByYear W21697948472016 @default.
- W2169794847 countsByYear W21697948472017 @default.
- W2169794847 countsByYear W21697948472018 @default.
- W2169794847 countsByYear W21697948472019 @default.
- W2169794847 countsByYear W21697948472020 @default.
- W2169794847 countsByYear W21697948472021 @default.
- W2169794847 countsByYear W21697948472022 @default.
- W2169794847 countsByYear W21697948472023 @default.