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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169800706> ?p ?o ?g. }

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• W2169800706 abstract "ABSTRACT The objective of the present study was to identify the optimal R207910-containing regimen to administer to patients who cannot receive rifampin (RIF) and isoniazid (INH) because of multidrug-resistant tuberculosis (MDR-TB), concomitant use of antiretroviral drugs, or toxicity. Mice were infected intravenously with 5 × 10 6 CFU of the H37Rv strain and treated five times per week with R207910 alone or various combinations of R207910 with the second-line drugs amikacin (AMK), pyrazinamide (PZA), moxifloxacin (MXF), and ethionamide (ETH). All R207910-containing regimens were significantly more active than the non-R207910-containing regimens after 1 month of therapy. When given for 2 months, R207910 alone was more active than the WHO standard first-line regimen RIF-INH-PZA. When R207910 was combined with second-line drugs, the combinations were more active than the currently recommended regimen of MDR-TB AMK-ETH-MXF-PZA, and culture negativity of both the lungs and spleen was reached after 2 months of treatment in almost every case." @default.
• W2169800706 created "2016-06-24" @default.
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• W2169800706 date "2006-11-01" @default.
• W2169800706 modified "2023-10-18" @default.
• W2169800706 title "Combinations of R207910 with Drugs Used To Treat Multidrug-Resistant Tuberculosis Have the Potential To Shorten Treatment Duration" @default.
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• W2169800706 doi "https://doi.org/10.1128/aac.00766-06" @default.
• W2169800706 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1635167" @default.
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