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- W2169808595 abstract "Recently a new form of the sulfonamide compounds was developed. This is the microcrystalline form produced by either sonic vibration or use of some rapid mixing device. 1 The chief difference from the ordinary sulfonamide compounds is the smaller size of the crystals, which renders more surface available and also permits passage through a 26 gage needle of concentrations as high as 20 per cent. Studies were undertaken in an attempt to evaluate this new physical property in ophthalmology. In a recent article 2 we showed that the ratio between the concentrations of sulfathiazole (2-[paraaminobenzenesulfonamido]-thiazole) in the aqueous and in the blood of cats with approximately the same with intraperitoneal injection of microcrystalline and oral administration of macrocrystalline sulfathiazole. Both Guyton 3 and Chinn and Bellows 4 have demonstrated the relatively greater penetration of sulfanilamide than of its derivatives when applied locally. They showed that sulfathiazole penetrated into the aqueous" @default.
- W2169808595 created "2016-06-24" @default.
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- W2169808595 date "1943-05-01" @default.
- W2169808595 modified "2023-09-26" @default.
- W2169808595 title "STUDIES WITH MICROCRYSTALLINE SULFATHIAZOLE" @default.
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- W2169808595 doi "https://doi.org/10.1001/archopht.1943.00880170131012" @default.
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