Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169811658> ?p ?o ?g. }
- W2169811658 endingPage "1024" @default.
- W2169811658 startingPage "1011" @default.
- W2169811658 abstract "Microfilaments are required for polarized growth and morphogenesis in Saccharomyces cerevisiae. To accomplish this, actin cables and patches are redistributed during the cell cycle to direct secretory components to appropriate sites for cell growth. A major component of actin cables is tropomyosin I, encoded by TPM1, that determines or stabilizes these structures. Disruption of TPM1 is not lethal but results in the loss of actin cables and confers a partial defect in polarized secretion. Using a synthetic lethal screen, we have identified seven mutations residing in six genes whose products are required in the absence of Tpm1p. Each mutant exhibited a morphological defect, suggesting a functional link to the actin cytoskeleton. Complementation cloning of one mutation revealed that it lies in BEM2, which encodes a GTPase-activating protein for the RHO1 product. bem2 mutations also show synthetic lethality with rho1 and mutations in certain other cytoskeletal genes (ACT1, MYO1, MYO2, and SAC6) but not with mutations in several noncytoskeletal genes. These data therefore provide a genetic link between the GAP encoded by BEM2 and the functional organization of microfilaments. In addition, we show that bem2 mutations confer benomyl sensitivity and have abnormal microtubule arrays, suggesting that the BEM2 product may also be involved directly or indirectly in regulating microtubule function." @default.
- W2169811658 created "2016-06-24" @default.
- W2169811658 creator A5043045724 @default.
- W2169811658 creator A5060464508 @default.
- W2169811658 date "1995-08-01" @default.
- W2169811658 modified "2023-09-23" @default.
- W2169811658 title "The rho-GAP encoded by BEM2 regulates cytoskeletal structure in budding yeast." @default.
- W2169811658 cites W1039027197 @default.
- W2169811658 cites W1492253723 @default.
- W2169811658 cites W1497947649 @default.
- W2169811658 cites W1502319840 @default.
- W2169811658 cites W1537782690 @default.
- W2169811658 cites W1591267603 @default.
- W2169811658 cites W1749612483 @default.
- W2169811658 cites W1765359824 @default.
- W2169811658 cites W1778706695 @default.
- W2169811658 cites W1784052398 @default.
- W2169811658 cites W1840742563 @default.
- W2169811658 cites W1875421809 @default.
- W2169811658 cites W1896977376 @default.
- W2169811658 cites W1916002325 @default.
- W2169811658 cites W1932699125 @default.
- W2169811658 cites W1956883206 @default.
- W2169811658 cites W1964073548 @default.
- W2169811658 cites W1967716439 @default.
- W2169811658 cites W1969737313 @default.
- W2169811658 cites W1971152163 @default.
- W2169811658 cites W1973671970 @default.
- W2169811658 cites W1973782344 @default.
- W2169811658 cites W1975335205 @default.
- W2169811658 cites W1980839154 @default.
- W2169811658 cites W1981990755 @default.
- W2169811658 cites W1987376594 @default.
- W2169811658 cites W1990651920 @default.
- W2169811658 cites W1993025857 @default.
- W2169811658 cites W1993972454 @default.
- W2169811658 cites W1994138436 @default.
- W2169811658 cites W1996144310 @default.
- W2169811658 cites W2001870577 @default.
- W2169811658 cites W2006506188 @default.
- W2169811658 cites W2007495904 @default.
- W2169811658 cites W2012807621 @default.
- W2169811658 cites W2015391676 @default.
- W2169811658 cites W2025232112 @default.
- W2169811658 cites W2026642300 @default.
- W2169811658 cites W2036145275 @default.
- W2169811658 cites W2036979978 @default.
- W2169811658 cites W2041520470 @default.
- W2169811658 cites W2052562460 @default.
- W2169811658 cites W2058919089 @default.
- W2169811658 cites W2061336319 @default.
- W2169811658 cites W2061365077 @default.
- W2169811658 cites W2077325701 @default.
- W2169811658 cites W2078188542 @default.
- W2169811658 cites W2080029470 @default.
- W2169811658 cites W2097186726 @default.
- W2169811658 cites W2115073295 @default.
- W2169811658 cites W2125781144 @default.
- W2169811658 cites W2130099579 @default.
- W2169811658 cites W2133112673 @default.
- W2169811658 cites W2135977869 @default.
- W2169811658 cites W2140849670 @default.
- W2169811658 cites W2141834983 @default.
- W2169811658 cites W2151702365 @default.
- W2169811658 cites W2152125010 @default.
- W2169811658 cites W2158726454 @default.
- W2169811658 cites W2164021052 @default.
- W2169811658 cites W2169333620 @default.
- W2169811658 cites W2171202879 @default.
- W2169811658 cites W2172673878 @default.
- W2169811658 cites W2173023130 @default.
- W2169811658 cites W2176511881 @default.
- W2169811658 cites W2177347112 @default.
- W2169811658 cites W2218185345 @default.
- W2169811658 cites W2220912830 @default.
- W2169811658 cites W2279940596 @default.
- W2169811658 cites W2288436650 @default.
- W2169811658 cites W2415905438 @default.
- W2169811658 cites W4240065971 @default.
- W2169811658 doi "https://doi.org/10.1091/mbc.6.8.1011" @default.
- W2169811658 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/301259" @default.
- W2169811658 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7579704" @default.
- W2169811658 hasPublicationYear "1995" @default.
- W2169811658 type Work @default.
- W2169811658 sameAs 2169811658 @default.
- W2169811658 citedByCount "62" @default.
- W2169811658 countsByYear W21698116582012 @default.
- W2169811658 countsByYear W21698116582013 @default.
- W2169811658 countsByYear W21698116582014 @default.
- W2169811658 countsByYear W21698116582020 @default.
- W2169811658 countsByYear W21698116582021 @default.
- W2169811658 countsByYear W21698116582022 @default.
- W2169811658 crossrefType "journal-article" @default.
- W2169811658 hasAuthorship W2169811658A5043045724 @default.
- W2169811658 hasAuthorship W2169811658A5060464508 @default.
- W2169811658 hasBestOaLocation W21698116582 @default.
- W2169811658 hasConcept C104317684 @default.
- W2169811658 hasConcept C125705527 @default.