FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169817963> ?p ?o ?g. }

• W2169817963 endingPage "883" @default.
• W2169817963 startingPage "877" @default.
• W2169817963 abstract "Summary Background and objective The MS4A2 gene, the β chain of the high‐affinity receptor for immunoglobulin (Ig)E, has previously been linked to atopy and asthma. The β‐chain of FcɛR1 enhances receptor maturation and signal transduction capacity, leading to the release of proinflammatory mediators and cytokines that can exacerbate the symptom of asthma. This study was performed to evaluate whether two genetic polymorphisms of the FcɛR1β gene (FcɛR1β−109T>C and FcɛR1β E237G) are associated with aspirin‐intolerant asthma (AIA). Methods The MS4A2 gene polymorphisms (FcɛR1β−109T>C and FcɛR1β E237G) were determined by SNP‐IT™ assays in patients with AIA ( N =164), aspirin‐tolerant asthma (ATA, N =144) and normal controls (NC, N =264) recruited from a Korean population. Results The genotype frequencies of FcɛR1β−109T>C and E237G polymorphisms were not significantly associated with the pathogenesis of AIA. However, FcɛR1β−109T>C polymorphism was significantly associated with the presence of specific IgE to Staphylococcal enterotoxin B (SEB); the number of subjects carrying both homozygous TT genotype of FcɛR1β−109T>C and specific IgE to SEB was significantly higher in the AIA group when compared with the other control groups ( P =0.01, odds ratio (OR)=7.723, 95% confidence interval (CI)=1.327–39.860 for AIA vs. ATA; P =0.02, OR=6.364, 95% CI=1.149∼35.229 for AIA vs. NC). In addition, luciferase reporter assays also showed that the FcɛR1β−109T allele was associated with higher promoter activity of MS4A2 in both RBL‐2H3 and A549 cell lines. Conclusion FcɛR1β−109T>C polymorphism may increase expression of MS4A2 by mast cells, leading to enhanced release of proinflammatory mediators in the asthmatic airway, contributing to increased susceptibility to AIA." @default.
• W2169817963 created "2016-06-24" @default.
• W2169817963 creator A5015144617 @default.
• W2169817963 creator A5029701198 @default.
• W2169817963 creator A5038852974 @default.
• W2169817963 creator A5066996390 @default.
• W2169817963 creator A5085642896 @default.
• W2169817963 creator A5086477416 @default.
• W2169817963 creator A5091351677 @default.
• W2169817963 date "2006-03-02" @default.
• W2169817963 modified "2023-10-15" @default.
• W2169817963 title "A polymorphism of MS4A2 (-109T>C) encoding the beta-chain of the high-affinity immunoglobulin E receptor (FceR1beta) is associated with a susceptibility to aspirin-intolerant asthma" @default.
• W2169817963 cites W1769055598 @default.
• W2169817963 cites W1879688395 @default.
• W2169817963 cites W1966870333 @default.
• W2169817963 cites W1979791806 @default.
• W2169817963 cites W1988036957 @default.
• W2169817963 cites W1991102173 @default.
• W2169817963 cites W1994589395 @default.
• W2169817963 cites W2002247332 @default.
• W2169817963 cites W2027724236 @default.
• W2169817963 cites W2030176117 @default.
• W2169817963 cites W2033330205 @default.
• W2169817963 cites W2034203371 @default.
• W2169817963 cites W2046024030 @default.
• W2169817963 cites W2056408010 @default.
• W2169817963 cites W2057488023 @default.
• W2169817963 cites W2102707743 @default.
• W2169817963 cites W2110604543 @default.
• W2169817963 cites W2129444769 @default.
• W2169817963 cites W2137081295 @default.
• W2169817963 cites W2166132450 @default.
• W2169817963 cites W2167730388 @default.
• W2169817963 cites W2169826337 @default.
• W2169817963 cites W2171094967 @default.
• W2169817963 cites W2189729843 @default.
• W2169817963 doi "https://doi.org/10.1111/j.1365-2222.2006.02443.x" @default.
• W2169817963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16839402" @default.
• W2169817963 hasPublicationYear "2006" @default.
• W2169817963 type Work @default.
• W2169817963 sameAs 2169817963 @default.
• W2169817963 citedByCount "49" @default.
• W2169817963 countsByYear W21698179632012 @default.
• W2169817963 countsByYear W21698179632013 @default.
• W2169817963 countsByYear W21698179632014 @default.
• W2169817963 countsByYear W21698179632015 @default.
• W2169817963 countsByYear W21698179632017 @default.
• W2169817963 countsByYear W21698179632018 @default.
• W2169817963 countsByYear W21698179632019 @default.
• W2169817963 countsByYear W21698179632020 @default.
• W2169817963 countsByYear W21698179632021 @default.
• W2169817963 countsByYear W21698179632022 @default.
• W2169817963 crossrefType "journal-article" @default.
• W2169817963 hasAuthorship W2169817963A5015144617 @default.
• W2169817963 hasAuthorship W2169817963A5029701198 @default.
• W2169817963 hasAuthorship W2169817963A5038852974 @default.
• W2169817963 hasAuthorship W2169817963A5066996390 @default.
• W2169817963 hasAuthorship W2169817963A5085642896 @default.
• W2169817963 hasAuthorship W2169817963A5086477416 @default.
• W2169817963 hasAuthorship W2169817963A5091351677 @default.
• W2169817963 hasConcept C104317684 @default.
• W2169817963 hasConcept C126322002 @default.
• W2169817963 hasConcept C135763542 @default.
• W2169817963 hasConcept C141105273 @default.
• W2169817963 hasConcept C156957248 @default.
• W2169817963 hasConcept C159654299 @default.
• W2169817963 hasConcept C180754005 @default.
• W2169817963 hasConcept C203014093 @default.
• W2169817963 hasConcept C2776042228 @default.
• W2169817963 hasConcept C2777697326 @default.
• W2169817963 hasConcept C2908647359 @default.
• W2169817963 hasConcept C54355233 @default.
• W2169817963 hasConcept C71924100 @default.
• W2169817963 hasConcept C86803240 @default.
• W2169817963 hasConcept C99454951 @default.
• W2169817963 hasConceptScore W2169817963C104317684 @default.
• W2169817963 hasConceptScore W2169817963C126322002 @default.
• W2169817963 hasConceptScore W2169817963C135763542 @default.
• W2169817963 hasConceptScore W2169817963C141105273 @default.
• W2169817963 hasConceptScore W2169817963C156957248 @default.
• W2169817963 hasConceptScore W2169817963C159654299 @default.
• W2169817963 hasConceptScore W2169817963C180754005 @default.
• W2169817963 hasConceptScore W2169817963C203014093 @default.
• W2169817963 hasConceptScore W2169817963C2776042228 @default.
• W2169817963 hasConceptScore W2169817963C2777697326 @default.
• W2169817963 hasConceptScore W2169817963C2908647359 @default.
• W2169817963 hasConceptScore W2169817963C54355233 @default.
• W2169817963 hasConceptScore W2169817963C71924100 @default.
• W2169817963 hasConceptScore W2169817963C86803240 @default.
• W2169817963 hasConceptScore W2169817963C99454951 @default.
• W2169817963 hasIssue "7" @default.
• W2169817963 hasLocation W21698179631 @default.
• W2169817963 hasLocation W21698179632 @default.
• W2169817963 hasOpenAccess W2169817963 @default.
• W2169817963 hasPrimaryLocation W21698179631 @default.
• W2169817963 hasRelatedWork W1947307702 @default.
• W2169817963 hasRelatedWork W1968123320 @default.
• W2169817963 hasRelatedWork W1988632115 @default.

• next