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• W2169824243 endingPage "1020" @default.
• W2169824243 startingPage "1006" @default.
• W2169824243 abstract "Abstract Learning Objectives After completing this course, the reader will be able to: Identify genetic polymorphisms within pharmacodynamic candidate genes that are potential predictive markers for treatment outcome with anticancer drugs.Describe treatment selection considerations in patients with cancer who have genetic polymorphisms that could influence pharmacodynamic aspects of anticancer therapy. CME This article is available for continuing medical education credit at CME.TheOncologist.com Response to treatment with anticancer drugs is subject to wide interindividual variability. This variability is expressed not only as differences in severity and type of toxicity, but also as differences in effectiveness. Variability in the constitution of genes involved in the pharmacokinetic and pharmacodynamic pathways of anticancer drugs has been shown to possibly translate into differences in treatment outcome. The overall knowledge in the field of pharmacogenetics has tremendously increased over the last couple of years, and has thereby provided opportunities for patient-tailored anticancer therapy. In previous parts of this series, we described pharmacogenetic variability in anticancer phase I and phase II drug metabolism and drug transport. This fourth part of a four-part series of reviews is focused on pharmacodynamic variability and encompasses genetic variation in drug target genes such as those encoding thymidylate synthase, methylene tetrahydrofolate reductase, and ribonucleotide reductase. Furthermore, genetic variability in other pharmacodynamic candidate genes involved in response to anticancer drugs is discussed, including genes involved in DNA repair such as those encoding excision repair crosscomplementing group 1 and group 2, x-ray crosscomplementing group 1 and group 3, and breast cancer genes 1 and 2. Finally, somatic mutations in KRAS and the gene encoding epidermal growth factor receptor (EGFR) and implications for EGFR-targeted drugs are discussed. Potential implications and opportunities for patient and drug selection for genotype-driven anticancer therapy are outlined." @default.
• W2169824243 created "2016-06-24" @default.
• W2169824243 creator A5000418012 @default.
• W2169824243 creator A5017478217 @default.
• W2169824243 creator A5062227574 @default.
• W2169824243 creator A5085647012 @default.
• W2169824243 date "2011-06-09" @default.
• W2169824243 modified "2023-10-17" @default.
• W2169824243 title "Part 4: Pharmacogenetic Variability in Anticancer Pharmacodynamic Drug Effects" @default.
• W2169824243 cites W102725257 @default.
• W2169824243 cites W1564499834 @default.
• W2169824243 cites W1797303364 @default.
• W2169824243 cites W180278647 @default.
• W2169824243 cites W1802949207 @default.
• W2169824243 cites W1880102547 @default.
• W2169824243 cites W1951925296 @default.
• W2169824243 cites W1966251853 @default.
• W2169824243 cites W1973268287 @default.
• W2169824243 cites W1974024530 @default.
• W2169824243 cites W1974452869 @default.
• W2169824243 cites W1974730203 @default.
• W2169824243 cites W1977439202 @default.
• W2169824243 cites W1979788220 @default.
• W2169824243 cites W1983863777 @default.
• W2169824243 cites W1985627636 @default.
• W2169824243 cites W1986462630 @default.
• W2169824243 cites W1988442083 @default.
• W2169824243 cites W1990763949 @default.
• W2169824243 cites W1997909925 @default.
• W2169824243 cites W1999250974 @default.
• W2169824243 cites W2001337137 @default.
• W2169824243 cites W2004718750 @default.
• W2169824243 cites W2009007206 @default.
• W2169824243 cites W2009388286 @default.
• W2169824243 cites W2009481811 @default.
• W2169824243 cites W2015620776 @default.
• W2169824243 cites W2016710415 @default.
• W2169824243 cites W2016717983 @default.
• W2169824243 cites W2018588892 @default.
• W2169824243 cites W2019847722 @default.
• W2169824243 cites W2021188441 @default.
• W2169824243 cites W2025074979 @default.
• W2169824243 cites W2025412572 @default.
• W2169824243 cites W2026727845 @default.
• W2169824243 cites W2030108537 @default.
• W2169824243 cites W2030883899 @default.
• W2169824243 cites W2031262735 @default.
• W2169824243 cites W2032480351 @default.
• W2169824243 cites W2033326364 @default.
• W2169824243 cites W2035205636 @default.
• W2169824243 cites W2040094592 @default.
• W2169824243 cites W2042143199 @default.
• W2169824243 cites W2043696829 @default.
• W2169824243 cites W2049601212 @default.
• W2169824243 cites W2049903904 @default.
• W2169824243 cites W2051184323 @default.
• W2169824243 cites W2055083952 @default.
• W2169824243 cites W2057706543 @default.
• W2169824243 cites W2058800908 @default.
• W2169824243 cites W2060571444 @default.
• W2169824243 cites W2062568878 @default.
• W2169824243 cites W2065022250 @default.
• W2169824243 cites W2065223298 @default.
• W2169824243 cites W2065829703 @default.
• W2169824243 cites W2066859729 @default.
• W2169824243 cites W2071161965 @default.
• W2169824243 cites W2079620909 @default.
• W2169824243 cites W2080719056 @default.
• W2169824243 cites W2081201480 @default.
• W2169824243 cites W2083634237 @default.
• W2169824243 cites W2083695927 @default.
• W2169824243 cites W2088293068 @default.
• W2169824243 cites W2089209606 @default.
• W2169824243 cites W2093922887 @default.
• W2169824243 cites W2095201384 @default.
• W2169824243 cites W2095618958 @default.
• W2169824243 cites W2095673635 @default.
• W2169824243 cites W2095807734 @default.
• W2169824243 cites W2098223440 @default.
• W2169824243 cites W2101329867 @default.
• W2169824243 cites W2104265571 @default.
• W2169824243 cites W2104477572 @default.
• W2169824243 cites W2104637985 @default.
• W2169824243 cites W2104748005 @default.
• W2169824243 cites W2105026490 @default.
• W2169824243 cites W2105202429 @default.
• W2169824243 cites W2106297623 @default.
• W2169824243 cites W2106789440 @default.
• W2169824243 cites W2108468456 @default.
• W2169824243 cites W2113363667 @default.
• W2169824243 cites W2115257917 @default.
• W2169824243 cites W2118004874 @default.
• W2169824243 cites W2118951956 @default.
• W2169824243 cites W2120490763 @default.
• W2169824243 cites W2121389354 @default.
• W2169824243 cites W2122551548 @default.
• W2169824243 cites W2122782025 @default.
• W2169824243 cites W2123322249 @default.

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