FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169838987> ?p ?o ?g. }

• W2169838987 endingPage "842" @default.
• W2169838987 startingPage "836" @default.
• W2169838987 abstract "In pregnant women, CYP3A activity increases by 100% during the third trimester (T3). Due to logistical and ethical constraints, little is known about the magnitude of CYP3A induction during the first trimester (T1) and second trimester (T2). Our laboratory has shown that sandwich-cultured human hepatocytes (SCHH) and HepaRG cells have the potential to predict the magnitude of in vivo induction of CYP3A activity likely to be observed in T1 and T2. Therefore, we incubated SCHH and HepaRG cells with plasma concentrations of various pregnancy-related hormones (PRHs)—individually or in combination—observed during T1, T2, or T3 in pregnant women. Then, CYP3A activity was measured by 1′-OH-midazolam formation. In all three trimesters, only cortisol (C) consistently and significantly induced CYP3A activity, while other individual hormones (progesterone, estradiol, or growth hormones) failed to induce CYP3A activity. At physiologically relevant 1× plasma concentrations, the magnitude of CYP3A induction by C or the combination of all PRHs did not change significantly with gestational age. The pattern of induction of CYP3A activity in SCHH by the hormones was similar to that in HepaRG cells. Based on these data, we conclude that C remains the major inducer of CYP3A activity earlier in gestation. Moreover, we predict that the magnitude of CYP3A induction during T1 and T2 will be similar to that observed during T3 (∼100% increase versus postpartum). This prediction is consistent with the observation of similar increases in T2 and T3 oral clearance of indinavir (a CYP3A cleared drug) versus postpartum." @default.
• W2169838987 created "2016-06-24" @default.
• W2169838987 creator A5010246066 @default.
• W2169838987 creator A5020600016 @default.
• W2169838987 creator A5041414501 @default.
• W2169838987 creator A5052124516 @default.
• W2169838987 creator A5081274753 @default.
• W2169838987 date "2015-03-23" @default.
• W2169838987 modified "2023-09-26" @default.
• W2169838987 title "Prediction of Gestational Age–Dependent Induction of In Vivo Hepatic CYP3A Activity Based on HepaRG Cells and Human Hepatocytes" @default.
• W2169838987 cites W1545442835 @default.
• W2169838987 cites W1609773580 @default.
• W2169838987 cites W1829170701 @default.
• W2169838987 cites W1925943257 @default.
• W2169838987 cites W1976914915 @default.
• W2169838987 cites W1979713715 @default.
• W2169838987 cites W1981314679 @default.
• W2169838987 cites W1982789243 @default.
• W2169838987 cites W1988653496 @default.
• W2169838987 cites W1988663155 @default.
• W2169838987 cites W1995623240 @default.
• W2169838987 cites W1998186490 @default.
• W2169838987 cites W1999334420 @default.
• W2169838987 cites W2003530931 @default.
• W2169838987 cites W2008430084 @default.
• W2169838987 cites W2019225079 @default.
• W2169838987 cites W2021776310 @default.
• W2169838987 cites W2024474319 @default.
• W2169838987 cites W2027517951 @default.
• W2169838987 cites W2035907933 @default.
• W2169838987 cites W2037383672 @default.
• W2169838987 cites W2048012100 @default.
• W2169838987 cites W2074576600 @default.
• W2169838987 cites W2075346453 @default.
• W2169838987 cites W2079760663 @default.
• W2169838987 cites W2084462922 @default.
• W2169838987 cites W2109103723 @default.
• W2169838987 cites W2116910113 @default.
• W2169838987 cites W2122368489 @default.
• W2169838987 cites W2128772465 @default.
• W2169838987 cites W2133499169 @default.
• W2169838987 cites W2137722420 @default.
• W2169838987 cites W2139462561 @default.
• W2169838987 cites W2142869955 @default.
• W2169838987 cites W2147181811 @default.
• W2169838987 cites W2154189263 @default.
• W2169838987 cites W2155882942 @default.
• W2169838987 cites W2157902463 @default.
• W2169838987 cites W2166861655 @default.
• W2169838987 cites W2225273737 @default.
• W2169838987 cites W2396293901 @default.
• W2169838987 doi "https://doi.org/10.1124/dmd.114.062984" @default.
• W2169838987 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4429679" @default.
• W2169838987 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25802327" @default.
• W2169838987 hasPublicationYear "2015" @default.
• W2169838987 type Work @default.
• W2169838987 sameAs 2169838987 @default.
• W2169838987 citedByCount "25" @default.
• W2169838987 countsByYear W21698389872016 @default.
• W2169838987 countsByYear W21698389872018 @default.
• W2169838987 countsByYear W21698389872019 @default.
• W2169838987 countsByYear W21698389872020 @default.
• W2169838987 countsByYear W21698389872021 @default.
• W2169838987 countsByYear W21698389872022 @default.
• W2169838987 countsByYear W21698389872023 @default.
• W2169838987 crossrefType "journal-article" @default.
• W2169838987 hasAuthorship W2169838987A5010246066 @default.
• W2169838987 hasAuthorship W2169838987A5020600016 @default.
• W2169838987 hasAuthorship W2169838987A5041414501 @default.
• W2169838987 hasAuthorship W2169838987A5052124516 @default.
• W2169838987 hasAuthorship W2169838987A5081274753 @default.
• W2169838987 hasBestOaLocation W21698389871 @default.
• W2169838987 hasConcept C11824378 @default.
• W2169838987 hasConcept C126322002 @default.
• W2169838987 hasConcept C134018914 @default.
• W2169838987 hasConcept C150903083 @default.
• W2169838987 hasConcept C185592680 @default.
• W2169838987 hasConcept C207001950 @default.
• W2169838987 hasConcept C2779234561 @default.
• W2169838987 hasConcept C46973012 @default.
• W2169838987 hasConcept C526171541 @default.
• W2169838987 hasConcept C54355233 @default.
• W2169838987 hasConcept C62231903 @default.
• W2169838987 hasConcept C71315377 @default.
• W2169838987 hasConcept C71924100 @default.
• W2169838987 hasConcept C86803240 @default.
• W2169838987 hasConceptScore W2169838987C11824378 @default.
• W2169838987 hasConceptScore W2169838987C126322002 @default.
• W2169838987 hasConceptScore W2169838987C134018914 @default.
• W2169838987 hasConceptScore W2169838987C150903083 @default.
• W2169838987 hasConceptScore W2169838987C185592680 @default.
• W2169838987 hasConceptScore W2169838987C207001950 @default.
• W2169838987 hasConceptScore W2169838987C2779234561 @default.
• W2169838987 hasConceptScore W2169838987C46973012 @default.
• W2169838987 hasConceptScore W2169838987C526171541 @default.
• W2169838987 hasConceptScore W2169838987C54355233 @default.
• W2169838987 hasConceptScore W2169838987C62231903 @default.
• W2169838987 hasConceptScore W2169838987C71315377 @default.

• next