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- W2169841941 abstract "Galectins constitute a family of proteins that bind to β-galactoside residues and have diverse physiological functions. Here we report on the identification of a galectin-like molecule, galectin-12, in a human adipose tissue cDNA library. The protein contained two potential carbohydrate-recognition domains with the second carbohydrate-recognition domain being less conserved compared with other galectins. <i>In vitro</i> translated galectin-12 bound to a lactosyl-agarose column far less efficiently than galectin-8. Galectin-12 mRNA was predominantly expressed in adipose tissue of human and mouse and in differentiated 3T3-L1 adipocytes. Caloric restriction and treatment of obese animals with troglitazone increased galectin-12 mRNA levels and decreased the average size of the cells in adipose tissue. The induction of galectin-12 expression by the thiazolidinedione, troglitazone, was paralleled by an increase in the number of apoptotic cells in adipose tissue. Immunocytochemical analysis revealed that galectin-12 was localized in the nucleus of adipocytes, and transfection with galectin-12 cDNA induced apoptosis of COS-1 cells. These results suggest that galectin-12, an adipose-expressed galectin-like molecule, may participate in the apoptosis of adipocytes." @default.
- W2169841941 created "2016-06-24" @default.
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- W2169841941 date "2001-09-01" @default.
- W2169841941 modified "2023-10-13" @default.
- W2169841941 title "Galectin-12, an Adipose-expressed Galectin-like Molecule Possessing Apoptosis-inducing Activity" @default.
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- W2169841941 doi "https://doi.org/10.1074/jbc.m105097200" @default.
- W2169841941 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11435439" @default.
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