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- W2169872693 abstract "Protein glycation is a non-enzymatic, irreversible modification of protein amino groups by reactive carbonyl species leading to the formation of advanced glycation end products (AGEs). Several proteins implicated in neurodegenerative diseases have been found to be glycated in vivo and the extent of glycation is related to the pathologies of the patients. Although it is now accepted that there is a direct correlation between AGEs formation and the development of neurodegenerative diseases related to protein misfolding and amyloid aggregation, several questions still remain unanswered: whether glycation is the triggering event or just an additional factor acting on the aggregation pathway. We have recently shown that glycation of the amyloidogenic W7FW14F apomyoglobin mutant significantly accelerates the amyloid fibrils formation providing evidence that glycation actively participates to the process. In the present study, to test if glycation can be considered also a triggering factor in amyloidosis, we evaluated the ability of different glycation agents to induce amyloid aggregation in the soluble wild-type apomyoglobin. Our results show that glycation covalently modifies apomyoglobin and induces conformational changes that lead to the formation of oligomeric species that are not implicated in amyloid aggregation. Thus, AGEs formation does not trigger amyloid aggregation in the wild-type apomyoglobin but only induce the formation of soluble oligomeric species able to affect cell viability. The molecular bases of cell toxicity induced by AGEs formed upon glycation of wild-type apomyoglobin have been also investigated." @default.
- W2169872693 created "2016-06-24" @default.
- W2169872693 creator A5012166735 @default.
- W2169872693 creator A5015158135 @default.
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- W2169872693 creator A5039682482 @default.
- W2169872693 creator A5072955762 @default.
- W2169872693 creator A5086152631 @default.
- W2169872693 date "2015-07-27" @default.
- W2169872693 modified "2023-10-18" @default.
- W2169872693 title "Glycation of Wild-Type Apomyoglobin Induces Formation of Highly Cytotoxic Oligomeric Species" @default.
- W2169872693 cites W1521958691 @default.
- W2169872693 cites W1530138639 @default.
- W2169872693 cites W1534773465 @default.
- W2169872693 cites W1547655165 @default.
- W2169872693 cites W1547902391 @default.
- W2169872693 cites W1554192230 @default.
- W2169872693 cites W1564273292 @default.
- W2169872693 cites W1966234811 @default.
- W2169872693 cites W1966527137 @default.
- W2169872693 cites W1969024078 @default.
- W2169872693 cites W1973897761 @default.
- W2169872693 cites W1974075993 @default.
- W2169872693 cites W1978051577 @default.
- W2169872693 cites W1978574835 @default.
- W2169872693 cites W1978617962 @default.
- W2169872693 cites W1983469460 @default.
- W2169872693 cites W1986572387 @default.
- W2169872693 cites W1987079564 @default.
- W2169872693 cites W1989270637 @default.
- W2169872693 cites W1989949137 @default.
- W2169872693 cites W1992380863 @default.
- W2169872693 cites W1993143422 @default.
- W2169872693 cites W1993429931 @default.
- W2169872693 cites W1999248724 @default.
- W2169872693 cites W2002076532 @default.
- W2169872693 cites W2002115616 @default.
- W2169872693 cites W2003473363 @default.
- W2169872693 cites W2005033167 @default.
- W2169872693 cites W2005068472 @default.
- W2169872693 cites W2005279391 @default.
- W2169872693 cites W2007017976 @default.
- W2169872693 cites W2007804077 @default.
- W2169872693 cites W2010474135 @default.
- W2169872693 cites W2010754688 @default.
- W2169872693 cites W2014113710 @default.
- W2169872693 cites W2018343943 @default.
- W2169872693 cites W2023291706 @default.
- W2169872693 cites W2024170704 @default.
- W2169872693 cites W2024895112 @default.
- W2169872693 cites W2025987695 @default.
- W2169872693 cites W2026473612 @default.
- W2169872693 cites W2028528940 @default.
- W2169872693 cites W2030864103 @default.
- W2169872693 cites W2032134987 @default.
- W2169872693 cites W2034578799 @default.
- W2169872693 cites W2036083522 @default.
- W2169872693 cites W2036885183 @default.
- W2169872693 cites W2037141143 @default.
- W2169872693 cites W2039877883 @default.
- W2169872693 cites W2040816104 @default.
- W2169872693 cites W2042885374 @default.
- W2169872693 cites W2044321635 @default.
- W2169872693 cites W2047797351 @default.
- W2169872693 cites W2048977657 @default.
- W2169872693 cites W2054526986 @default.
- W2169872693 cites W2055352476 @default.
- W2169872693 cites W2055378374 @default.
- W2169872693 cites W2061463827 @default.
- W2169872693 cites W2062828530 @default.
- W2169872693 cites W2068722076 @default.
- W2169872693 cites W2071266931 @default.
- W2169872693 cites W2076508298 @default.
- W2169872693 cites W2082677113 @default.
- W2169872693 cites W2086327676 @default.
- W2169872693 cites W2087497084 @default.
- W2169872693 cites W2089491263 @default.
- W2169872693 cites W2094784672 @default.
- W2169872693 cites W2098536205 @default.
- W2169872693 cites W2100109707 @default.
- W2169872693 cites W2104307385 @default.
- W2169872693 cites W2108762011 @default.
- W2169872693 cites W2109116451 @default.
- W2169872693 cites W2110385915 @default.
- W2169872693 cites W2115664678 @default.
- W2169872693 cites W2120705179 @default.
- W2169872693 cites W2121753059 @default.
- W2169872693 cites W2136522112 @default.
- W2169872693 cites W2147222782 @default.
- W2169872693 cites W2149527585 @default.
- W2169872693 cites W2153290883 @default.
- W2169872693 cites W2153439292 @default.
- W2169872693 cites W2154154964 @default.
- W2169872693 cites W2161713694 @default.
- W2169872693 cites W2165186407 @default.
- W2169872693 cites W2168994316 @default.
- W2169872693 cites W2317228589 @default.
- W2169872693 cites W4233862330 @default.