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- W2169881885 abstract "Introduction Targeted agents have tremendously improved the course of disease in patients with metastatic renal cell carcinoma (mRCC). Based on their superiority over interferon and/or placebo, 3 agents have been approved for first-line treatment of patients with favorable or intermediate risk (according to the Memorial Sloan-Kettering Cancer Center [MSKCC] risk group classification/criteria); they include sunitinib, bevacizumab in combination with interferon-alfa, and pazopanib. The intravenous mammalian target of rapamycin (mTOR) inhibitor temsirolimus has been considered standard of care for patients with poor prognostic features. So far the longest median overall survival has been observed with the oral tyrosine kinase inhibitor (TKI) sunitinib, which is currently considered first-line standard of care in patients with mRCC. In a randomized phase III trial, sunitinib was shown to provide a statistically significant benefit in terms of progression-free survival (PFS) when compared with interferon-alfa (PFS 11 vs. 5 months, respectively). The recommended ose of sunitinib is 50 mg/d for 4 weeks, followed by 2 weeks off treatent. In the case of severe or unmanageable adverse events, a dose reuction to 37.5 mg continuously might be considered. In second-line treatment—based on the results of a randomized, lacebo-controlled trial—the current guidelines recommend the oral" @default.
- W2169881885 created "2016-06-24" @default.
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- W2169881885 date "2012-12-01" @default.
- W2169881885 modified "2023-10-05" @default.
- W2169881885 title "Dose Matters: The Importance of Appropriate Dosing: A Case Report on Sunitinib Treatment in a Patient With Metastatic Renal Cell Carcinoma" @default.
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- W2169881885 doi "https://doi.org/10.1016/j.clgc.2012.04.005" @default.
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