FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169884611> ?p ?o ?g. }

• W2169884611 endingPage "2252" @default.
• W2169884611 startingPage "2245" @default.
• W2169884611 abstract "OBJECTIVE— Genetic variants in the fat mass and obesity-associated (FTO) gene have been linked with obesity and type 2 diabetes in European populations. We aimed to test the role of FTO genetic variants in obesity and type 2 diabetes in the Chinese population. RESEARCH DESIGN AND METHODS— We genotyped 19 single-nucleotide polymorphisms (SNPs) spanning from the 3′ end of the neighboring RPGRIP1L gene to the 5′ flanking region of the FTO gene. We analyzed their associations with obesity (638 case and 1,610 control subjects), type 2 diabetes (759 case and 784 control subjects), and obesity-related traits in nondiabetic subjects. RESULTS— Among the 19 SNPs, the rs9939609 A allele was strongly associated with obesity (P = 7.0 × 10−4) and BMI (P = 0.0024) in the Chinese population. The odds ratio for obesity was 2.60 (95% CI 1.24–5.46) (P = 0.011) for the AA genotype and 1.32 (1.05–1.66) (P = 0.018) for the AT genotype compared with the TT genotype. Each additional copy of the rs9936609 A allele was associated with a BMI increase of ∼0.37 kg/m2. The rs9939609 A allele was substantially less common in the Chinese population than in the European population (12.6 vs. 45%). We did not find significant associations of the 19 SNPs with type 2 diabetes or other obesity-related traits. CONCLUSIONS— Genetic variation in the FTO gene is strongly associated with obesity and BMI in the Chinese population. The risk variant is less common in the Chinese population, but its effect size on BMI is comparable with that in the European population." @default.
• W2169884611 created "2016-06-24" @default.
• W2169884611 creator A5019520168 @default.
• W2169884611 creator A5024876582 @default.
• W2169884611 creator A5033802039 @default.
• W2169884611 creator A5038117854 @default.
• W2169884611 creator A5046278846 @default.
• W2169884611 creator A5060831778 @default.
• W2169884611 creator A5067929020 @default.
• W2169884611 creator A5068733168 @default.
• W2169884611 creator A5084643836 @default.
• W2169884611 date "2008-08-01" @default.
• W2169884611 modified "2023-10-17" @default.
• W2169884611 title "Common Variation in the Fat Mass and Obesity-Associated (<i>FTO</i>) Gene Confers Risk of Obesity and Modulates BMI in the Chinese Population" @default.
• W2169884611 cites W1944558458 @default.
• W2169884611 cites W1964292199 @default.
• W2169884611 cites W1969673534 @default.
• W2169884611 cites W1972276090 @default.
• W2169884611 cites W1984217495 @default.
• W2169884611 cites W1994130453 @default.
• W2169884611 cites W2001423848 @default.
• W2169884611 cites W2003629248 @default.
• W2169884611 cites W2026446409 @default.
• W2169884611 cites W2028335133 @default.
• W2169884611 cites W2029121047 @default.
• W2169884611 cites W2048755332 @default.
• W2169884611 cites W2058401000 @default.
• W2169884611 cites W2059588512 @default.
• W2169884611 cites W2076225138 @default.
• W2169884611 cites W2082122713 @default.
• W2169884611 cites W2097660065 @default.
• W2169884611 cites W2110678911 @default.
• W2169884611 cites W2123005049 @default.
• W2169884611 cites W2124185446 @default.
• W2169884611 cites W2126718294 @default.
• W2169884611 cites W2136681918 @default.
• W2169884611 cites W2139098554 @default.
• W2169884611 cites W2149385661 @default.
• W2169884611 cites W2149512324 @default.
• W2169884611 cites W2160234571 @default.
• W2169884611 cites W2161633633 @default.
• W2169884611 cites W2162530578 @default.
• W2169884611 cites W4213243604 @default.
• W2169884611 doi "https://doi.org/10.2337/db08-0377" @default.
• W2169884611 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2494679" @default.
• W2169884611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18487448" @default.
• W2169884611 hasPublicationYear "2008" @default.
• W2169884611 type Work @default.
• W2169884611 sameAs 2169884611 @default.
• W2169884611 citedByCount "205" @default.
• W2169884611 countsByYear W21698846112012 @default.
• W2169884611 countsByYear W21698846112013 @default.
• W2169884611 countsByYear W21698846112014 @default.
• W2169884611 countsByYear W21698846112015 @default.
• W2169884611 countsByYear W21698846112016 @default.
• W2169884611 countsByYear W21698846112017 @default.
• W2169884611 countsByYear W21698846112018 @default.
• W2169884611 countsByYear W21698846112019 @default.
• W2169884611 countsByYear W21698846112020 @default.
• W2169884611 countsByYear W21698846112021 @default.
• W2169884611 countsByYear W21698846112022 @default.
• W2169884611 countsByYear W21698846112023 @default.
• W2169884611 crossrefType "journal-article" @default.
• W2169884611 hasAuthorship W2169884611A5019520168 @default.
• W2169884611 hasAuthorship W2169884611A5024876582 @default.
• W2169884611 hasAuthorship W2169884611A5033802039 @default.
• W2169884611 hasAuthorship W2169884611A5038117854 @default.
• W2169884611 hasAuthorship W2169884611A5046278846 @default.
• W2169884611 hasAuthorship W2169884611A5060831778 @default.
• W2169884611 hasAuthorship W2169884611A5067929020 @default.
• W2169884611 hasAuthorship W2169884611A5068733168 @default.
• W2169884611 hasAuthorship W2169884611A5084643836 @default.
• W2169884611 hasBestOaLocation W21698846111 @default.
• W2169884611 hasConcept C104317684 @default.
• W2169884611 hasConcept C126322002 @default.
• W2169884611 hasConcept C134018914 @default.
• W2169884611 hasConcept C135763542 @default.
• W2169884611 hasConcept C153209595 @default.
• W2169884611 hasConcept C156957248 @default.
• W2169884611 hasConcept C180754005 @default.
• W2169884611 hasConcept C2777180221 @default.
• W2169884611 hasConcept C2780221984 @default.
• W2169884611 hasConcept C2780428817 @default.
• W2169884611 hasConcept C2908647359 @default.
• W2169884611 hasConcept C511355011 @default.
• W2169884611 hasConcept C54355233 @default.
• W2169884611 hasConcept C555293320 @default.
• W2169884611 hasConcept C71924100 @default.
• W2169884611 hasConcept C86803240 @default.
• W2169884611 hasConcept C99454951 @default.
• W2169884611 hasConceptScore W2169884611C104317684 @default.
• W2169884611 hasConceptScore W2169884611C126322002 @default.
• W2169884611 hasConceptScore W2169884611C134018914 @default.
• W2169884611 hasConceptScore W2169884611C135763542 @default.
• W2169884611 hasConceptScore W2169884611C153209595 @default.
• W2169884611 hasConceptScore W2169884611C156957248 @default.
• W2169884611 hasConceptScore W2169884611C180754005 @default.
• W2169884611 hasConceptScore W2169884611C2777180221 @default.

• next