FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169896356> ?p ?o ?g. }

• W2169896356 endingPage "1160" @default.
• W2169896356 startingPage "1154" @default.
• W2169896356 abstract "Cells respond to external stimuli through networks of regulatory interactions. The human pathogen Mycobacterium tuberculosis responds to stress encountered during infection by arresting multiplication and implementing critical metabolic changes that lead to or sustain the nonreplicative state. Much of this differentiation program is recapitulated when M. tuberculosis cultures are subjected to gradual oxygen depletion in vitro. Here we report that hypoxic induction of critical central metabolism genes in the glyoxylate shunt (icl1) and in the methylcitrate cycle (gltA1) involves both global and local regulators. The global regulators are accessory sigma factors σ(B) for icl1 and σ(E) for gltA1. The local regulators are the products of two paralogous genes mapping at positions adjacent to the corresponding effector gene or operon. We call these genes lrpI and lrpG (for local regulatory protein of icl1 and gltA1). We also found that (i) each sigma factor controls the corresponding local regulator, (ii) both global and local regulators are required for effector gene induction, and (iii) the occurrence of sigma factor control of effector gene induction is independent of its control over the corresponding local regulator. Together, these data indicate that induction of icl1 and gltA1 utilizes parallel feed-forward loops with an AND input function. Both feed-forward loops are affected by σ(E), since this sigma factor is part of the gltA1 loop and controls sigB in the icl1 loop. Feed-forward loops may critically contribute to the cellular developmental program associated with M. tuberculosis dormancy." @default.
• W2169896356 created "2016-06-24" @default.
• W2169896356 creator A5013835810 @default.
• W2169896356 creator A5050076723 @default.
• W2169896356 creator A5050470562 @default.
• W2169896356 creator A5082454420 @default.
• W2169896356 creator A5083062157 @default.
• W2169896356 date "2011-03-01" @default.
• W2169896356 modified "2023-09-23" @default.
• W2169896356 title "Regulation of Central Metabolism Genes of <i>Mycobacterium tuberculosis</i> by Parallel Feed-Forward Loops Controlled by Sigma Factor E (σ ^E )" @default.
• W2169896356 cites W1549522998 @default.
• W2169896356 cites W1559223366 @default.
• W2169896356 cites W1864461701 @default.
• W2169896356 cites W1966638085 @default.
• W2169896356 cites W1985293833 @default.
• W2169896356 cites W1993086228 @default.
• W2169896356 cites W1999663880 @default.
• W2169896356 cites W2000425923 @default.
• W2169896356 cites W2021059161 @default.
• W2169896356 cites W2023061016 @default.
• W2169896356 cites W2043952643 @default.
• W2169896356 cites W2053867514 @default.
• W2169896356 cites W2065675200 @default.
• W2169896356 cites W2068337438 @default.
• W2169896356 cites W2077403395 @default.
• W2169896356 cites W2090902470 @default.
• W2169896356 cites W2096606273 @default.
• W2169896356 cites W2106767919 @default.
• W2169896356 cites W2107443178 @default.
• W2169896356 cites W2109110326 @default.
• W2169896356 cites W2110699703 @default.
• W2169896356 cites W2123084649 @default.
• W2169896356 cites W2123847681 @default.
• W2169896356 cites W2133378792 @default.
• W2169896356 cites W2147057508 @default.
• W2169896356 cites W2154292013 @default.
• W2169896356 cites W2158023121 @default.
• W2169896356 cites W2158408911 @default.
• W2169896356 cites W2160319713 @default.
• W2169896356 cites W2163156346 @default.
• W2169896356 cites W2165259074 @default.
• W2169896356 cites W2166915670 @default.
• W2169896356 doi "https://doi.org/10.1128/jb.00459-10" @default.
• W2169896356 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3067603" @default.
• W2169896356 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21193605" @default.
• W2169896356 hasPublicationYear "2011" @default.
• W2169896356 type Work @default.
• W2169896356 sameAs 2169896356 @default.
• W2169896356 citedByCount "29" @default.
• W2169896356 countsByYear W21698963562012 @default.
• W2169896356 countsByYear W21698963562013 @default.
• W2169896356 countsByYear W21698963562014 @default.
• W2169896356 countsByYear W21698963562015 @default.
• W2169896356 countsByYear W21698963562016 @default.
• W2169896356 countsByYear W21698963562017 @default.
• W2169896356 countsByYear W21698963562018 @default.
• W2169896356 countsByYear W21698963562019 @default.
• W2169896356 countsByYear W21698963562020 @default.
• W2169896356 countsByYear W21698963562021 @default.
• W2169896356 countsByYear W21698963562022 @default.
• W2169896356 crossrefType "journal-article" @default.
• W2169896356 hasAuthorship W2169896356A5013835810 @default.
• W2169896356 hasAuthorship W2169896356A5050076723 @default.
• W2169896356 hasAuthorship W2169896356A5050470562 @default.
• W2169896356 hasAuthorship W2169896356A5082454420 @default.
• W2169896356 hasAuthorship W2169896356A5083062157 @default.
• W2169896356 hasBestOaLocation W21698963561 @default.
• W2169896356 hasConcept C101762097 @default.
• W2169896356 hasConcept C104317684 @default.
• W2169896356 hasConcept C150194340 @default.
• W2169896356 hasConcept C203075996 @default.
• W2169896356 hasConcept C47319516 @default.
• W2169896356 hasConcept C51785407 @default.
• W2169896356 hasConcept C54355233 @default.
• W2169896356 hasConcept C547475151 @default.
• W2169896356 hasConcept C6929976 @default.
• W2169896356 hasConcept C86803240 @default.
• W2169896356 hasConcept C95444343 @default.
• W2169896356 hasConceptScore W2169896356C101762097 @default.
• W2169896356 hasConceptScore W2169896356C104317684 @default.
• W2169896356 hasConceptScore W2169896356C150194340 @default.
• W2169896356 hasConceptScore W2169896356C203075996 @default.
• W2169896356 hasConceptScore W2169896356C47319516 @default.
• W2169896356 hasConceptScore W2169896356C51785407 @default.
• W2169896356 hasConceptScore W2169896356C54355233 @default.
• W2169896356 hasConceptScore W2169896356C547475151 @default.
• W2169896356 hasConceptScore W2169896356C6929976 @default.
• W2169896356 hasConceptScore W2169896356C86803240 @default.
• W2169896356 hasConceptScore W2169896356C95444343 @default.
• W2169896356 hasIssue "5" @default.
• W2169896356 hasLocation W21698963561 @default.
• W2169896356 hasLocation W21698963562 @default.
• W2169896356 hasLocation W21698963563 @default.
• W2169896356 hasLocation W21698963564 @default.
• W2169896356 hasOpenAccess W2169896356 @default.
• W2169896356 hasPrimaryLocation W21698963561 @default.
• W2169896356 hasRelatedWork W1547401425 @default.
• W2169896356 hasRelatedWork W1972880328 @default.

• next