FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169954069> ?p ?o ?g. }

• W2169954069 endingPage "415" @default.
• W2169954069 startingPage "403" @default.
• W2169954069 abstract "The neurofibromatosis 2 (NF2) suppressor gene encodes a protein termed merlin (or schwannomin) with sequence similarity to a family of proteins that link the actin cytoskeleton to cell surface glycoproteins. Members of this ERM family of proteins include ezrin, radixin, and moesin. These proteins contain a carboxyl (C-) terminus actin binding site. In contrast to the ERM proteins, merlin lacks the conventional C-terminal actin binding site, but still localizes to the ruffling edge of plasma membranes. In this study, we investigate the ability of merlin to interact with actin through a nonconventional actin binding domain. We demonstrate for the first time that merlin can associate with polymerized actin in vitro by virtue of an amino (N-) terminal actin binding domain including residues 178–367. Merlin actin binding is not affected by several naturally-occurring NF2 patient mutations or alternatively spliced isoforms. These results suggest that merlin, like other ERM proteins, can directly interact with the actin cytoskeleton. In addition, merlin associates with polymerized microtubules in vitro using a novel microtubule binding region in the N-terminal region of merlin that is masked in the full-length merlin molecule, such that wild-type functional merlin in the “closed” conformation fails to bind polymerized microtubules. These microtubule association results confirm the notion that merlin exists in “open” and “closed” conformations relevant to its function as a negative growth regulator. J. Neurosci. Res. 51:403–415, 1998. © 1998 Wiley-Liss, Inc." @default.
• W2169954069 created "2016-06-24" @default.
• W2169954069 creator A5061887921 @default.
• W2169954069 creator A5081965993 @default.
• W2169954069 date "1998-02-01" @default.
• W2169954069 modified "2023-10-18" @default.
• W2169954069 title "Merlin differentially associates with the microtubule and actin cytoskeleton" @default.
• W2169954069 cites W1966081096 @default.
• W2169954069 cites W1966980518 @default.
• W2169954069 cites W1987696730 @default.
• W2169954069 cites W1995263093 @default.
• W2169954069 cites W1996275548 @default.
• W2169954069 cites W1997224206 @default.
• W2169954069 cites W2007660746 @default.
• W2169954069 cites W2013584525 @default.
• W2169954069 cites W2020993672 @default.
• W2169954069 cites W2029976610 @default.
• W2169954069 cites W2044764402 @default.
• W2169954069 cites W2066605427 @default.
• W2169954069 cites W2069777477 @default.
• W2169954069 cites W2073468932 @default.
• W2169954069 cites W2080377199 @default.
• W2169954069 cites W2090336665 @default.
• W2169954069 cites W2090369455 @default.
• W2169954069 cites W2100868490 @default.
• W2169954069 cites W2114964393 @default.
• W2169954069 cites W2115799757 @default.
• W2169954069 cites W2144472910 @default.
• W2169954069 cites W2144476583 @default.
• W2169954069 cites W2159711375 @default.
• W2169954069 cites W2161807488 @default.
• W2169954069 cites W2171366439 @default.
• W2169954069 cites W2188658958 @default.
• W2169954069 cites W2315552227 @default.
• W2169954069 cites W2415494887 @default.
• W2169954069 cites W74923221 @default.
• W2169954069 doi "https://doi.org/10.1002/(sici)1097-4547(19980201)51:3<403::aid-jnr13>3.0.co;2-7" @default.
• W2169954069 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9486775" @default.
• W2169954069 hasPublicationYear "1998" @default.
• W2169954069 type Work @default.
• W2169954069 sameAs 2169954069 @default.
• W2169954069 citedByCount "157" @default.
• W2169954069 countsByYear W21699540692012 @default.
• W2169954069 countsByYear W21699540692013 @default.
• W2169954069 countsByYear W21699540692014 @default.
• W2169954069 countsByYear W21699540692015 @default.
• W2169954069 countsByYear W21699540692016 @default.
• W2169954069 countsByYear W21699540692017 @default.
• W2169954069 countsByYear W21699540692018 @default.
• W2169954069 countsByYear W21699540692019 @default.
• W2169954069 countsByYear W21699540692020 @default.
• W2169954069 countsByYear W21699540692021 @default.
• W2169954069 countsByYear W21699540692023 @default.
• W2169954069 crossrefType "journal-article" @default.
• W2169954069 hasAuthorship W2169954069A5061887921 @default.
• W2169954069 hasAuthorship W2169954069A5081965993 @default.
• W2169954069 hasConcept C104317684 @default.
• W2169954069 hasConcept C125705527 @default.
• W2169954069 hasConcept C130861313 @default.
• W2169954069 hasConcept C142669718 @default.
• W2169954069 hasConcept C1491633281 @default.
• W2169954069 hasConcept C178628643 @default.
• W2169954069 hasConcept C179185449 @default.
• W2169954069 hasConcept C185592680 @default.
• W2169954069 hasConcept C196509110 @default.
• W2169954069 hasConcept C20418707 @default.
• W2169954069 hasConcept C2776292417 @default.
• W2169954069 hasConcept C2780246058 @default.
• W2169954069 hasConcept C2993400109 @default.
• W2169954069 hasConcept C3620293 @default.
• W2169954069 hasConcept C54355233 @default.
• W2169954069 hasConcept C59999672 @default.
• W2169954069 hasConcept C86803240 @default.
• W2169954069 hasConcept C95444343 @default.
• W2169954069 hasConceptScore W2169954069C104317684 @default.
• W2169954069 hasConceptScore W2169954069C125705527 @default.
• W2169954069 hasConceptScore W2169954069C130861313 @default.
• W2169954069 hasConceptScore W2169954069C142669718 @default.
• W2169954069 hasConceptScore W2169954069C1491633281 @default.
• W2169954069 hasConceptScore W2169954069C178628643 @default.
• W2169954069 hasConceptScore W2169954069C179185449 @default.
• W2169954069 hasConceptScore W2169954069C185592680 @default.
• W2169954069 hasConceptScore W2169954069C196509110 @default.
• W2169954069 hasConceptScore W2169954069C20418707 @default.
• W2169954069 hasConceptScore W2169954069C2776292417 @default.
• W2169954069 hasConceptScore W2169954069C2780246058 @default.
• W2169954069 hasConceptScore W2169954069C2993400109 @default.
• W2169954069 hasConceptScore W2169954069C3620293 @default.
• W2169954069 hasConceptScore W2169954069C54355233 @default.
• W2169954069 hasConceptScore W2169954069C59999672 @default.
• W2169954069 hasConceptScore W2169954069C86803240 @default.
• W2169954069 hasConceptScore W2169954069C95444343 @default.
• W2169954069 hasIssue "3" @default.
• W2169954069 hasLocation W21699540691 @default.
• W2169954069 hasLocation W21699540692 @default.
• W2169954069 hasOpenAccess W2169954069 @default.
• W2169954069 hasPrimaryLocation W21699540691 @default.
• W2169954069 hasRelatedWork W1976965279 @default.

• next