FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169962504> ?p ?o ?g. }

• W2169962504 endingPage "394" @default.
• W2169962504 startingPage "385" @default.
• W2169962504 abstract "Arylamine N-acetyltransferase (NAT) polymorphism in humans has been associated with variation in susceptibility to drug toxicity and cancer. In mice, three NAT isoenzymes are encoded by Nat1, Nat2 and Nat3 genes. Only Nat2 has been shown previously to be polymorphic, a single nucleotide substitution causing the slow acetylator phenotype in the A/J strain. We sequenced the Nat genes from inbred (CBA and 129/Ola), outbred (PO and TO) and wild-derived inbred (Mus spretus and Mus musculus castaneus) mouse strains and report polymorphism in all three Nat genes of M. spretus and in Nat2 and Nat3 genes of M. m. castaneus. Enzymatic activity assays using liver homogenates demonstrated that M. m. castaneus is a 'fast' and M. spretus a 'slow' acetylator. Western blot analysis indicated that hepatic NAT2 protein is less abundant in M. spretus than M. m. castaneus. The new allozymes were expressed in a mammalian cell line and NAT enzymatic activity was measured with a series of substrates. NAT1 and NAT2 isoenzymes of M. m. castaneus exhibited a higher rate of acetylation, compared with those of M. spretus. Activity of the NAT3 allozymes was hardly detectable, although the Nat3 gene does appear to be transcribed, since mRNA was detected by RT-PCR in the spleen. Additional polymorphisms, useful for Nat-related genetic studies, have been identified between BALB/c, C57Bl/6J, A/J, 129/Ola, CBA, PO, TO, M. m. castaneus and M. spretus strains in four microsatellite repeats located close to the Nat genes." @default.
• W2169962504 created "2016-06-24" @default.
• W2169962504 creator A5009319585 @default.
• W2169962504 creator A5071196257 @default.
• W2169962504 creator A5074347850 @default.
• W2169962504 date "2002-07-01" @default.
• W2169962504 modified "2023-09-24" @default.
• W2169962504 title "Identification and functional characterization of novel polymorphisms associated with the genes for arylamine N-acetyltransferases in mice" @default.
• W2169962504 cites W1516667778 @default.
• W2169962504 cites W1525464385 @default.
• W2169962504 cites W1580220829 @default.
• W2169962504 cites W1757108108 @default.
• W2169962504 cites W1852786350 @default.
• W2169962504 cites W1980571658 @default.
• W2169962504 cites W1983116428 @default.
• W2169962504 cites W1990449229 @default.
• W2169962504 cites W1995575073 @default.
• W2169962504 cites W1998260637 @default.
• W2169962504 cites W2000498456 @default.
• W2169962504 cites W2009252429 @default.
• W2169962504 cites W2017545241 @default.
• W2169962504 cites W2023098611 @default.
• W2169962504 cites W2035137179 @default.
• W2169962504 cites W2039408159 @default.
• W2169962504 cites W2042897001 @default.
• W2169962504 cites W2051792801 @default.
• W2169962504 cites W2053867451 @default.
• W2169962504 cites W2055266236 @default.
• W2169962504 cites W2066959869 @default.
• W2169962504 cites W2070928296 @default.
• W2169962504 cites W2071301032 @default.
• W2169962504 cites W2074093254 @default.
• W2169962504 cites W2074944649 @default.
• W2169962504 cites W2093380647 @default.
• W2169962504 cites W2100289966 @default.
• W2169962504 cites W2103808653 @default.
• W2169962504 cites W2116704368 @default.
• W2169962504 cites W2118335777 @default.
• W2169962504 cites W2122656085 @default.
• W2169962504 cites W2133700798 @default.
• W2169962504 cites W2147683761 @default.
• W2169962504 cites W2148353957 @default.
• W2169962504 cites W2155331961 @default.
• W2169962504 cites W2157908205 @default.
• W2169962504 cites W2161137131 @default.
• W2169962504 cites W2182953926 @default.
• W2169962504 cites W2183574692 @default.
• W2169962504 cites W2221470806 @default.
• W2169962504 cites W2295786067 @default.
• W2169962504 cites W2338245921 @default.
• W2169962504 cites W4251176812 @default.
• W2169962504 cites W4293247451 @default.
• W2169962504 doi "https://doi.org/10.1097/00008571-200207000-00006" @default.
• W2169962504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12142728" @default.
• W2169962504 hasPublicationYear "2002" @default.
• W2169962504 type Work @default.
• W2169962504 sameAs 2169962504 @default.
• W2169962504 citedByCount "34" @default.
• W2169962504 countsByYear W21699625042012 @default.
• W2169962504 countsByYear W21699625042013 @default.
• W2169962504 countsByYear W21699625042014 @default.
• W2169962504 countsByYear W21699625042016 @default.
• W2169962504 countsByYear W21699625042018 @default.
• W2169962504 countsByYear W21699625042019 @default.
• W2169962504 countsByYear W21699625042020 @default.
• W2169962504 countsByYear W21699625042021 @default.
• W2169962504 countsByYear W21699625042022 @default.
• W2169962504 crossrefType "journal-article" @default.
• W2169962504 hasAuthorship W2169962504A5009319585 @default.
• W2169962504 hasAuthorship W2169962504A5071196257 @default.
• W2169962504 hasAuthorship W2169962504A5074347850 @default.
• W2169962504 hasConcept C104317684 @default.
• W2169962504 hasConcept C119795356 @default.
• W2169962504 hasConcept C135763542 @default.
• W2169962504 hasConcept C153911025 @default.
• W2169962504 hasConcept C181199279 @default.
• W2169962504 hasConcept C182516595 @default.
• W2169962504 hasConcept C2778328694 @default.
• W2169962504 hasConcept C31258907 @default.
• W2169962504 hasConcept C41008148 @default.
• W2169962504 hasConcept C54355233 @default.
• W2169962504 hasConcept C55493867 @default.
• W2169962504 hasConcept C86803240 @default.
• W2169962504 hasConceptScore W2169962504C104317684 @default.
• W2169962504 hasConceptScore W2169962504C119795356 @default.
• W2169962504 hasConceptScore W2169962504C135763542 @default.
• W2169962504 hasConceptScore W2169962504C153911025 @default.
• W2169962504 hasConceptScore W2169962504C181199279 @default.
• W2169962504 hasConceptScore W2169962504C182516595 @default.
• W2169962504 hasConceptScore W2169962504C2778328694 @default.
• W2169962504 hasConceptScore W2169962504C31258907 @default.
• W2169962504 hasConceptScore W2169962504C41008148 @default.
• W2169962504 hasConceptScore W2169962504C54355233 @default.
• W2169962504 hasConceptScore W2169962504C55493867 @default.
• W2169962504 hasConceptScore W2169962504C86803240 @default.
• W2169962504 hasIssue "5" @default.
• W2169962504 hasLocation W21699625041 @default.
• W2169962504 hasLocation W21699625042 @default.

• next