FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169964842> ?p ?o ?g. }

• W2169964842 endingPage "90" @default.
• W2169964842 startingPage "80" @default.
• W2169964842 abstract "Cell membrane proteins play an important role in tissue architecture and cell-cell communication. We hypothesize that segmentation and multidimensional characterization of the distribution of cell membrane proteins, on a cell-by-cell basis, enable improved classification of treatment groups and identify important characteristics that can otherwise be hidden. We have developed a series of computational steps to 1) delineate cell membrane protein signals and associate them with a specific nucleus; 2) compute a coupled representation of the multiplexed DNA content with membrane proteins; 3) rank computed features associated with such a multidimensional representation; 4) visualize selected features for comparative evaluation through heatmaps; and 5) discriminate between treatment groups in an optimal fashion. The novelty of our method is in the segmentation of the membrane signal and the multidimensional representation of phenotypic signature on a cell-by-cell basis. To test the utility of this method, the proposed computational steps were applied to images of cells that have been irradiated with different radiation qualities in the presence and absence of other small molecules. These samples are labeled for their DNA content and E-cadherin membrane proteins. We demonstrate that multidimensional representations of cell-by-cell phenotypes improve predictive and visualization capabilities among different treatment groups, and identify hidden variables." @default.
• W2169964842 created "2016-06-24" @default.
• W2169964842 creator A5036013825 @default.
• W2169964842 creator A5047619963 @default.
• W2169964842 creator A5053749724 @default.
• W2169964842 creator A5054902187 @default.
• W2169964842 creator A5055404450 @default.
• W2169964842 creator A5062551209 @default.
• W2169964842 date "2010-01-01" @default.
• W2169964842 modified "2023-10-16" @default.
• W2169964842 title "Multidimensional Profiling of Cell Surface Proteins and Nuclear Markers" @default.
• W2169964842 cites W1553616550 @default.
• W2169964842 cites W1563088657 @default.
• W2169964842 cites W1967532587 @default.
• W2169964842 cites W1984162437 @default.
• W2169964842 cites W2014132511 @default.
• W2169964842 cites W2025994539 @default.
• W2169964842 cites W2037586865 @default.
• W2169964842 cites W2041353769 @default.
• W2169964842 cites W2056459831 @default.
• W2169964842 cites W2075744820 @default.
• W2169964842 cites W2094497914 @default.
• W2169964842 cites W2108303909 @default.
• W2169964842 cites W2114487471 @default.
• W2169964842 cites W2118364944 @default.
• W2169964842 cites W2167435976 @default.
• W2169964842 cites W2168166653 @default.
• W2169964842 doi "https://doi.org/10.1109/tcbb.2008.134" @default.
• W2169964842 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20150670" @default.
• W2169964842 hasPublicationYear "2010" @default.
• W2169964842 type Work @default.
• W2169964842 sameAs 2169964842 @default.
• W2169964842 citedByCount "15" @default.
• W2169964842 countsByYear W21699648422012 @default.
• W2169964842 countsByYear W21699648422013 @default.
• W2169964842 countsByYear W21699648422014 @default.
• W2169964842 countsByYear W21699648422015 @default.
• W2169964842 countsByYear W21699648422018 @default.
• W2169964842 countsByYear W21699648422019 @default.
• W2169964842 crossrefType "journal-article" @default.
• W2169964842 hasAuthorship W2169964842A5036013825 @default.
• W2169964842 hasAuthorship W2169964842A5047619963 @default.
• W2169964842 hasAuthorship W2169964842A5053749724 @default.
• W2169964842 hasAuthorship W2169964842A5054902187 @default.
• W2169964842 hasAuthorship W2169964842A5055404450 @default.
• W2169964842 hasAuthorship W2169964842A5062551209 @default.
• W2169964842 hasBestOaLocation W21699648423 @default.
• W2169964842 hasConcept C104317684 @default.
• W2169964842 hasConcept C140051345 @default.
• W2169964842 hasConcept C144647389 @default.
• W2169964842 hasConcept C1491633281 @default.
• W2169964842 hasConcept C153180895 @default.
• W2169964842 hasConcept C154945302 @default.
• W2169964842 hasConcept C17744445 @default.
• W2169964842 hasConcept C186060115 @default.
• W2169964842 hasConcept C199539241 @default.
• W2169964842 hasConcept C2776359362 @default.
• W2169964842 hasConcept C2778106830 @default.
• W2169964842 hasConcept C36464697 @default.
• W2169964842 hasConcept C41008148 @default.
• W2169964842 hasConcept C41625074 @default.
• W2169964842 hasConcept C54355233 @default.
• W2169964842 hasConcept C70721500 @default.
• W2169964842 hasConcept C86803240 @default.
• W2169964842 hasConcept C89600930 @default.
• W2169964842 hasConcept C94625758 @default.
• W2169964842 hasConceptScore W2169964842C104317684 @default.
• W2169964842 hasConceptScore W2169964842C140051345 @default.
• W2169964842 hasConceptScore W2169964842C144647389 @default.
• W2169964842 hasConceptScore W2169964842C1491633281 @default.
• W2169964842 hasConceptScore W2169964842C153180895 @default.
• W2169964842 hasConceptScore W2169964842C154945302 @default.
• W2169964842 hasConceptScore W2169964842C17744445 @default.
• W2169964842 hasConceptScore W2169964842C186060115 @default.
• W2169964842 hasConceptScore W2169964842C199539241 @default.
• W2169964842 hasConceptScore W2169964842C2776359362 @default.
• W2169964842 hasConceptScore W2169964842C2778106830 @default.
• W2169964842 hasConceptScore W2169964842C36464697 @default.
• W2169964842 hasConceptScore W2169964842C41008148 @default.
• W2169964842 hasConceptScore W2169964842C41625074 @default.
• W2169964842 hasConceptScore W2169964842C54355233 @default.
• W2169964842 hasConceptScore W2169964842C70721500 @default.
• W2169964842 hasConceptScore W2169964842C86803240 @default.
• W2169964842 hasConceptScore W2169964842C89600930 @default.
• W2169964842 hasConceptScore W2169964842C94625758 @default.
• W2169964842 hasIssue "1" @default.
• W2169964842 hasLocation W21699648421 @default.
• W2169964842 hasLocation W21699648422 @default.
• W2169964842 hasLocation W21699648423 @default.
• W2169964842 hasLocation W21699648424 @default.
• W2169964842 hasLocation W21699648425 @default.
• W2169964842 hasOpenAccess W2169964842 @default.
• W2169964842 hasPrimaryLocation W21699648421 @default.
• W2169964842 hasRelatedWork W1961048777 @default.
• W2169964842 hasRelatedWork W2021549593 @default.
• W2169964842 hasRelatedWork W2022902413 @default.
• W2169964842 hasRelatedWork W2045441408 @default.
• W2169964842 hasRelatedWork W2058058781 @default.

• next